A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical Meristem

ABSTRACT Plant growth and development rely on a delicate balance between cell proliferation and cell differentiation. The root apical meristem (RAM) of Arabidopsis thaliana is an excellent model to study the cell cycle due to the coordinated relationship between nucleus shape and cell size at each s...

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Main Authors: J. Irepan Reyes‐Olalde, Miguel Tapia‐Rodríguez, Vadim Pérez‐Koldenkova, Gastón Contreras‐Jiménez, Paul Hernández‐Herrera, Gabriel Corkidi, Arturo J. Arciniega‐González, Maria De La Paz‐Sánchez, Berenice García‐Ponce, Adriana Garay‐Arroyo, Elena R. Álvarez‐Buylla
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Plant Direct
Subjects:
Online Access:https://doi.org/10.1002/pld3.70060
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author J. Irepan Reyes‐Olalde
Miguel Tapia‐Rodríguez
Vadim Pérez‐Koldenkova
Gastón Contreras‐Jiménez
Paul Hernández‐Herrera
Gabriel Corkidi
Arturo J. Arciniega‐González
Maria De La Paz‐Sánchez
Berenice García‐Ponce
Adriana Garay‐Arroyo
Elena R. Álvarez‐Buylla
author_facet J. Irepan Reyes‐Olalde
Miguel Tapia‐Rodríguez
Vadim Pérez‐Koldenkova
Gastón Contreras‐Jiménez
Paul Hernández‐Herrera
Gabriel Corkidi
Arturo J. Arciniega‐González
Maria De La Paz‐Sánchez
Berenice García‐Ponce
Adriana Garay‐Arroyo
Elena R. Álvarez‐Buylla
author_sort J. Irepan Reyes‐Olalde
collection DOAJ
description ABSTRACT Plant growth and development rely on a delicate balance between cell proliferation and cell differentiation. The root apical meristem (RAM) of Arabidopsis thaliana is an excellent model to study the cell cycle due to the coordinated relationship between nucleus shape and cell size at each stage, allowing for precise estimation of the cell cycle duration. In this study, we present a method for high‐resolution visualization of RAM cells. This is the first protocol that allows for simultaneous high‐resolution imaging of cellular and nuclear stains, being compatible with DNA replication markers such as EdU, including fluorescent proteins (H2B::YFP), SYTOX DNA stains, and the cell wall stain SR2200. This protocol includes a clarification procedure that enables the acquisition of high‐resolution 3D images, suitable for detailed subsequent analysis.
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spelling doaj-art-5da26d207f724b56bb3de2b263531d872025-08-20T02:29:34ZengWileyPlant Direct2475-44552025-03-0194n/an/a10.1002/pld3.70060A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical MeristemJ. Irepan Reyes‐Olalde0Miguel Tapia‐Rodríguez1Vadim Pérez‐Koldenkova2Gastón Contreras‐Jiménez3Paul Hernández‐Herrera4Gabriel Corkidi5Arturo J. Arciniega‐González6Maria De La Paz‐Sánchez7Berenice García‐Ponce8Adriana Garay‐Arroyo9Elena R. Álvarez‐Buylla10Laboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoUnidad de Microscopía, Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoLaboratorio Nacional de Microscopía Avanzada, Centro Médico Nacional Siglo XXI‐IMSS Instituto Mexicano del Seguro Social Ciudad de México MexicoLaboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoDepartamento de Ingenería Celular y Biocatálisis, Laboratorio de Imágenes y Visión por Computadora Instituto de Biotecnología, UNAM Cuernavaca MéxicoDepartamento de Ingenería Celular y Biocatálisis, Laboratorio de Imágenes y Visión por Computadora Instituto de Biotecnología, UNAM Cuernavaca MéxicoLaboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoLaboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoLaboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoLaboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoLaboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología Universidad Nacional Autónoma de México, Ciudad Universitaria Ciudad de México MéxicoABSTRACT Plant growth and development rely on a delicate balance between cell proliferation and cell differentiation. The root apical meristem (RAM) of Arabidopsis thaliana is an excellent model to study the cell cycle due to the coordinated relationship between nucleus shape and cell size at each stage, allowing for precise estimation of the cell cycle duration. In this study, we present a method for high‐resolution visualization of RAM cells. This is the first protocol that allows for simultaneous high‐resolution imaging of cellular and nuclear stains, being compatible with DNA replication markers such as EdU, including fluorescent proteins (H2B::YFP), SYTOX DNA stains, and the cell wall stain SR2200. This protocol includes a clarification procedure that enables the acquisition of high‐resolution 3D images, suitable for detailed subsequent analysis.https://doi.org/10.1002/pld3.700605‐ethynyl‐2‐deoxyuridine (EdU)cell and nuclear markerscell cycleroot apical meristem
spellingShingle J. Irepan Reyes‐Olalde
Miguel Tapia‐Rodríguez
Vadim Pérez‐Koldenkova
Gastón Contreras‐Jiménez
Paul Hernández‐Herrera
Gabriel Corkidi
Arturo J. Arciniega‐González
Maria De La Paz‐Sánchez
Berenice García‐Ponce
Adriana Garay‐Arroyo
Elena R. Álvarez‐Buylla
A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical Meristem
Plant Direct
5‐ethynyl‐2‐deoxyuridine (EdU)
cell and nuclear markers
cell cycle
root apical meristem
title A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical Meristem
title_full A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical Meristem
title_fullStr A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical Meristem
title_full_unstemmed A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical Meristem
title_short A Method to Visualize Cell Proliferation of Arabidopsis thaliana: A Case Study of the Root Apical Meristem
title_sort method to visualize cell proliferation of arabidopsis thaliana a case study of the root apical meristem
topic 5‐ethynyl‐2‐deoxyuridine (EdU)
cell and nuclear markers
cell cycle
root apical meristem
url https://doi.org/10.1002/pld3.70060
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