The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study
Objectives. We aimed to assess the variation of insulin sensitivity in relation to obesity in women living with PCOS in a sub-Sahara African setting. Methods. We studied body composition, insulin sensitivity, and resting energy expenditure in 14 PCOS patients (6 obese and 8 nonobese) compared to 10...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/9201701 |
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| author | Emmanuella Doh Armand Mbanya Jean Dupont Kemfang-Ngowa Sama Dohbit Mycilline Tchana-Sinou Pascal Foumane Olivier Trésor Donfack Anderson S. Doh Jean Claude Mbanya Eugene Sobngwi |
| author_facet | Emmanuella Doh Armand Mbanya Jean Dupont Kemfang-Ngowa Sama Dohbit Mycilline Tchana-Sinou Pascal Foumane Olivier Trésor Donfack Anderson S. Doh Jean Claude Mbanya Eugene Sobngwi |
| author_sort | Emmanuella Doh |
| collection | DOAJ |
| description | Objectives. We aimed to assess the variation of insulin sensitivity in relation to obesity in women living with PCOS in a sub-Sahara African setting. Methods. We studied body composition, insulin sensitivity, and resting energy expenditure in 14 PCOS patients (6 obese and 8 nonobese) compared to 10 matched nonobese non-PCOS subjects. Insulin sensitivity was assessed using the gold standard 80 mU/m2/min euglycemic-hyperinsulinemic clamp and resting energy expenditure was measured by indirect calorimetry. Results. Insulin sensitivity adjusted to lean mass was lowest in obese PCOS subjects and highest in healthy subjects (11.2 [10.1–12.4] versus 12.9 [12.1–13.8] versus 16.6 [13.8–17.9], p=0.012); there was a tendency for resting energy expenditure adjusted for total body mass to decrease across the groups highest in obese PCOS subjects (1411 [1368–1613] versus 1274 [1174–1355] versus 1239 [1195–1454], p=0.306). Conclusion. In this sub-Saharan population, insulin resistance is associated with PCOS per se but is further aggravated by obesity. Obesity did not seem to be explained by low resting energy expenditure suggesting that dietary intake may be a determinant of the obesity in this context. |
| format | Article |
| id | doaj-art-5da14de2e814402099bf2ea170f91543 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5da14de2e814402099bf2ea170f915432025-08-20T03:34:45ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/92017019201701The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp StudyEmmanuella Doh0Armand Mbanya1Jean Dupont Kemfang-Ngowa2Sama Dohbit3Mycilline Tchana-Sinou4Pascal Foumane5Olivier Trésor Donfack6Anderson S. Doh7Jean Claude Mbanya8Eugene Sobngwi9National Obesity Center, Yaoundé Central Hospital, Yaoundé, CameroonNational Obesity Center, Yaoundé Central Hospital, Yaoundé, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CameroonYaoundé General Hospital, Yaoundé, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CameroonLaboratory of Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé 1, Yaoundé, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CameroonNational Obesity Center, Yaoundé Central Hospital, Yaoundé, CameroonNational Obesity Center, Yaoundé Central Hospital, Yaoundé, CameroonObjectives. We aimed to assess the variation of insulin sensitivity in relation to obesity in women living with PCOS in a sub-Sahara African setting. Methods. We studied body composition, insulin sensitivity, and resting energy expenditure in 14 PCOS patients (6 obese and 8 nonobese) compared to 10 matched nonobese non-PCOS subjects. Insulin sensitivity was assessed using the gold standard 80 mU/m2/min euglycemic-hyperinsulinemic clamp and resting energy expenditure was measured by indirect calorimetry. Results. Insulin sensitivity adjusted to lean mass was lowest in obese PCOS subjects and highest in healthy subjects (11.2 [10.1–12.4] versus 12.9 [12.1–13.8] versus 16.6 [13.8–17.9], p=0.012); there was a tendency for resting energy expenditure adjusted for total body mass to decrease across the groups highest in obese PCOS subjects (1411 [1368–1613] versus 1274 [1174–1355] versus 1239 [1195–1454], p=0.306). Conclusion. In this sub-Saharan population, insulin resistance is associated with PCOS per se but is further aggravated by obesity. Obesity did not seem to be explained by low resting energy expenditure suggesting that dietary intake may be a determinant of the obesity in this context.http://dx.doi.org/10.1155/2016/9201701 |
| spellingShingle | Emmanuella Doh Armand Mbanya Jean Dupont Kemfang-Ngowa Sama Dohbit Mycilline Tchana-Sinou Pascal Foumane Olivier Trésor Donfack Anderson S. Doh Jean Claude Mbanya Eugene Sobngwi The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study International Journal of Endocrinology |
| title | The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study |
| title_full | The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study |
| title_fullStr | The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study |
| title_full_unstemmed | The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study |
| title_short | The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study |
| title_sort | relationship between adiposity and insulin sensitivity in african women living with the polycystic ovarian syndrome a clamp study |
| url | http://dx.doi.org/10.1155/2016/9201701 |
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