Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery

Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery

Nowadays, the development of drug-loaded electrospun organic-inorganic composite scaffolds for tissue engineering application is an attractive approach. In this study, a composite scaffold of Poly-l-lactic acid (PLLA) incorporated dexamethasone (Dexa) loaded Mesoporous Silica Nanoparticles (MSN) coa...

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Main Authors: Mohammad Porgham Daryasari, Mehdi Dusti Telgerd, Mohammad Hossein Karami, Ali Zandi-Karimi, Hamid Akbarijavar, Mehdi Khoobi, Ehsan Seyedjafari, Gebremariam Birhanu, Pegah Khosravian, Fatemeh SadatMahdavi
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Mesoporous silica nanoparticles
electrospinning
Poly-l-lactic acid
chitosan
dexamethasone
composite scaffold
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1658594
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