Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada

Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada

The GsGd lineage (A/goose/Guangdong/1/1996) H5N1 virus was introduced to Canada in 2021/2022 through the Atlantic and East Asia-Australasia/Pacific flyways by migratory birds. This was followed by unprecedented outbreaks affecting domestic and wild birds, with spillover into other animals. Here, we...

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Main Authors: Tamiru N. Alkie, Sherri Cox, Carissa Embury-Hyatt, Brian Stevens, Neil Pople, Margo J. Pybus, Wanhong Xu, Tamiko Hisanaga, Matthew Suderman, Janice Koziuk, Peter Kruczkiewicz, Hoang Hai Nguyen, Mathew Fisher, Oliver Lung, Cassidy N. G. Erdelyan, Orie Hochman, Davor Ojkic, Carmencita Yason, Maria Bravo-Araya, Laura Bourque, Trent K. Bollinger, Catherine Soos, Jolene Giacinti, Jennifer Provencher, Sarah Ogilvie, Amanda Clark, Robyn MacPhee, Glen J. Parsons, Hazel Eaglesome, Sayrah Gilbert, Kelsey Saboraki, Richard Davis, Alexandra Jerao, Matthew Ginn, Megan E.B. Jones, Yohannes Berhane
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
Clade 2.3.4.4b
HPAI
H5N1
reassortment
mutation
mammals
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2186608
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