Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations
BackgroundHypovitaminosis, or vitamin deficiency, has been increasingly recognized as a potential contributing factor in the development of recurrent aphthous stomatitis (RAS), a condition characterized by the periodic formation of painful ulcers in the oral mucosa.Materials and methodsThis mini rev...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1520067/full |
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| author | Alessio Rosa Giovanni Cianconi Riccardo De Angelis Alberto Maria Pujia Claudio Arcuri |
| author_facet | Alessio Rosa Giovanni Cianconi Riccardo De Angelis Alberto Maria Pujia Claudio Arcuri |
| author_sort | Alessio Rosa |
| collection | DOAJ |
| description | BackgroundHypovitaminosis, or vitamin deficiency, has been increasingly recognized as a potential contributing factor in the development of recurrent aphthous stomatitis (RAS), a condition characterized by the periodic formation of painful ulcers in the oral mucosa.Materials and methodsThis mini review includes a literature search on PubMed, Web of Science, and Scopus databases using keywords “hypovitaminosis AND aphthous ulcers.”ResultsThere is a growing body of evidence supporting the link between various vitamin deficiencies—particularly vitamins B12, C, and folate—and the prevalence of RAS, with implications for both diagnosis and management.ConclusionThis review aims to outline the clinical and biochemical findings associated with hypovitaminosis in individuals presenting with RAS, emphasizing the diagnostic importance of recognizing vitamin deficiencies in these patients and exploring possible therapeutic approaches. |
| format | Article |
| id | doaj-art-5d9763cd271048aa801c08f09c347428 |
| institution | Kabale University |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-5d9763cd271048aa801c08f09c3474282025-01-28T06:41:30ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-01-01610.3389/froh.2025.15200671520067Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerationsAlessio Rosa0Giovanni Cianconi1Riccardo De Angelis2Alberto Maria Pujia3Claudio Arcuri4Department of Chemical Science and Technologies, Dentistry, University of Rome Tor Vergata, Rome, ItalyDepartment of Chemical Science and Technologies, Dentistry, University of Rome Tor Vergata, Rome, ItalyDepartment of Chemical Science and Technologies, Dentistry, University of Rome Tor Vergata, Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, ItalyDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, ItalyBackgroundHypovitaminosis, or vitamin deficiency, has been increasingly recognized as a potential contributing factor in the development of recurrent aphthous stomatitis (RAS), a condition characterized by the periodic formation of painful ulcers in the oral mucosa.Materials and methodsThis mini review includes a literature search on PubMed, Web of Science, and Scopus databases using keywords “hypovitaminosis AND aphthous ulcers.”ResultsThere is a growing body of evidence supporting the link between various vitamin deficiencies—particularly vitamins B12, C, and folate—and the prevalence of RAS, with implications for both diagnosis and management.ConclusionThis review aims to outline the clinical and biochemical findings associated with hypovitaminosis in individuals presenting with RAS, emphasizing the diagnostic importance of recognizing vitamin deficiencies in these patients and exploring possible therapeutic approaches.https://www.frontiersin.org/articles/10.3389/froh.2025.1520067/fullhypovitaminosisaphthous ulcersvitamin deficiencyrecurrent aphthous stomatitisoral health |
| spellingShingle | Alessio Rosa Giovanni Cianconi Riccardo De Angelis Alberto Maria Pujia Claudio Arcuri Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations Frontiers in Oral Health hypovitaminosis aphthous ulcers vitamin deficiency recurrent aphthous stomatitis oral health |
| title | Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations |
| title_full | Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations |
| title_fullStr | Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations |
| title_full_unstemmed | Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations |
| title_short | Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations |
| title_sort | hypovitaminosis and its association with recurrent aphthous stomatitis a comprehensive review of clinical correlations and diagnostic considerations |
| topic | hypovitaminosis aphthous ulcers vitamin deficiency recurrent aphthous stomatitis oral health |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1520067/full |
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