LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS
Aim. To investigate whether low and intermediate density lipoprotein (LDL, IDL) subfractions are associated with a degree of angiographically verified coronary atherosclerosis, as well as with other biochemical risk factors of coronary heart disease (CHD), and hypertriglyceridemia (HTG) in particula...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2013-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/207 |
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| author | I. N. Ozerova N. V. Perova V. A. Metelskaya O. I. Chernushevich N. E. Gavrilova |
| author_facet | I. N. Ozerova N. V. Perova V. A. Metelskaya O. I. Chernushevich N. E. Gavrilova |
| author_sort | I. N. Ozerova |
| collection | DOAJ |
| description | Aim. To investigate whether low and intermediate density lipoprotein (LDL, IDL) subfractions are associated with a degree of angiographically verified coronary atherosclerosis, as well as with other biochemical risk factors of coronary heart disease (CHD), and hypertriglyceridemia (HTG) in particular.Material and methods. The study included 129 patients (76 men and 53 women), aged 33–75 years, who were referred for coronary angiography. All participants were divided into three groups by the degree of coronary artery (CA) stenosis: 0–20%, 21–70%, and >70%. LDL and IDL subfractions were measured with the Lipoprint LDL System (electrophoresis in 3% polyacrylamide gel).Results. All groups were similar by the levels of lipid and apoprotein parameters. The levels of high-sensitive C-reactive protein and glucose, as well as HOMA-IR index, were higher in Group 3 patients. In most cases of severe CA stenosis, small dense LDL particles were detected. In HTG patients, higher levels of small dense LDL3 particles were registered only together with the CA stenosis of at least 21–70%.Conclusion. The findings on lipoprotein subfractions, obtained with the Lipoprint LDL System, have demonstrated that in patients with verified coronary atherosclerosis, there is a link between the levels of more atherogenic small dense LDL3 particles, the degree of CA stenosis, and blood TG levels. The combination of HTG and high LDL3 levels could be considered an additional marker of severe CA atherosclerosis. |
| format | Article |
| id | doaj-art-5d947aeebe4e49cf84f00ddd282523cc |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2013-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-5d947aeebe4e49cf84f00ddd282523cc2025-08-20T02:59:53Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252013-08-01124162010.15829/1728-8800-2013-4-16-20207LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSISI. N. Ozerova0N. V. Perova1V. A. Metelskaya2O. I. Chernushevich3N. E. Gavrilova4State Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowAim. To investigate whether low and intermediate density lipoprotein (LDL, IDL) subfractions are associated with a degree of angiographically verified coronary atherosclerosis, as well as with other biochemical risk factors of coronary heart disease (CHD), and hypertriglyceridemia (HTG) in particular.Material and methods. The study included 129 patients (76 men and 53 women), aged 33–75 years, who were referred for coronary angiography. All participants were divided into three groups by the degree of coronary artery (CA) stenosis: 0–20%, 21–70%, and >70%. LDL and IDL subfractions were measured with the Lipoprint LDL System (electrophoresis in 3% polyacrylamide gel).Results. All groups were similar by the levels of lipid and apoprotein parameters. The levels of high-sensitive C-reactive protein and glucose, as well as HOMA-IR index, were higher in Group 3 patients. In most cases of severe CA stenosis, small dense LDL particles were detected. In HTG patients, higher levels of small dense LDL3 particles were registered only together with the CA stenosis of at least 21–70%.Conclusion. The findings on lipoprotein subfractions, obtained with the Lipoprint LDL System, have demonstrated that in patients with verified coronary atherosclerosis, there is a link between the levels of more atherogenic small dense LDL3 particles, the degree of CA stenosis, and blood TG levels. The combination of HTG and high LDL3 levels could be considered an additional marker of severe CA atherosclerosis.https://cardiovascular.elpub.ru/jour/article/view/207small dense ldl particlescoronary atherosclerosisvarying degree of coronary stenosislipoprint ldl system |
| spellingShingle | I. N. Ozerova N. V. Perova V. A. Metelskaya O. I. Chernushevich N. E. Gavrilova LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS Кардиоваскулярная терапия и профилактика small dense ldl particles coronary atherosclerosis varying degree of coronary stenosis lipoprint ldl system |
| title | LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS |
| title_full | LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS |
| title_fullStr | LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS |
| title_full_unstemmed | LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS |
| title_short | LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS |
| title_sort | low density lipoprotein subfractions and varying degree of coronary stenosis |
| topic | small dense ldl particles coronary atherosclerosis varying degree of coronary stenosis lipoprint ldl system |
| url | https://cardiovascular.elpub.ru/jour/article/view/207 |
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