Effects of Anti-GPIbαantibody on the expression of platelet GPIbα,CD62P and CD63 in maintenance hemodialysis patients
Objective To explore the effects of anti-platelet membrane glycoprotein Ib alpha(GPIbα)antibody on the expression of peripheral GPIbα,alpha particle membrane glycoprotein(CD62 P)and lysosomal membrane protein(CD63)in maintenance hemodialysis(MHD)patients.Methods Thirty-seven patients with chronic re...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2018-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57914471&Fpath=home&index=0 |
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| Summary: | Objective To explore the effects of anti-platelet membrane glycoprotein Ib alpha(GPIbα)antibody on the expression of peripheral GPIbα,alpha particle membrane glycoprotein(CD62 P)and lysosomal membrane protein(CD63)in maintenance hemodialysis(MHD)patients.Methods Thirty-seven patients with chronic renal failure undergoing MHD from March 2016 to March 2018 in the Department of Nephrology in Eighth Affiliated Hospital of Sun Yat-sen University and 31 healthy people in the Physical Examination Center were enrolled in this study.Using flow cytomery,the expression of platelet member GPIbα,CD62 P and CD63 was detected before and after addition of anti-GPIbαantibody in MHD patients.Results The expression of platelet membrane GPIbαin no antibody treatment group(29.9±4.9)% was significantly lower than in control group(63.8±9.0)%and antibody treatment group(42.3±6.5)%(both P<0.01).The expression of CD62 P and CD63 in no antibody treatment group(50.9±7.5)% and(54.1±5.5)% was significantly higher than that in the control group(23.3±8.7% and 30.9±6.2%)and antibody treatment group(36.5±2.0)% and(47.2±2.2)%(P<0.01,P<0.05).Conclusions Anti-GPIbαantibody can regulate platelet function and activity by up-regulating the expression of platelet membrane GPIbα,and down-regulating the expression of CD62 P and CD63 in MHD patients,as a result to suppress adhesion and aggregation of platelets and thrombosis,and reduce the possibility of thromboembolism events in MHD patients. |
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| ISSN: | 1671-2390 |