Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis
Abstract Background Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes (T2D). Lipoprotein(a) [Lp(a)], a known cardiovascular risk factor, has been hypothesized to influence the development of DPN. This meta-analysis aimed to investigate the relationship between Lp(a) le...
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BMC
2025-03-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01621-y |
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| author | Li Sheng Yiwen Yang Yunqing Zhou |
| author_facet | Li Sheng Yiwen Yang Yunqing Zhou |
| author_sort | Li Sheng |
| collection | DOAJ |
| description | Abstract Background Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes (T2D). Lipoprotein(a) [Lp(a)], a known cardiovascular risk factor, has been hypothesized to influence the development of DPN. This meta-analysis aimed to investigate the relationship between Lp(a) levels and DPN in patients with T2D. Methods Following PRISMA 2020 guidelines, a systematic search of PubMed, Embase, Web of Science, Wanfang, and CNKI databases was performed up to October 12, 2024. Observational studies assessing blood Lp(a) levels in T2D patients with and without DPN or evaluating the association between Lp(a) and DPN risk were included. Data synthesis utilized a random-effects model to calculate standardized mean differences (SMDs) and odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Results Eleven studies with 18,022 patients were included. Patients with DPN had significantly higher Lp(a) levels than those without DPN (SMD: 0.10, 95% CI: 0.02–0.19, p = 0.01; I² = 43%). High Lp(a) levels were associated with DPN (OR: 1.31, 95% CI: 1.07–1.60, p = 0.009; I² = 62%). Subgroup analyses according to study design, mean age of the patients, methods for measuring Lp(a) concentration, cutoff values of a high Lp(a), and study quality scores showed consistent results (p for subgroup difference all > 0.05). A high Lp(a) was associated with DPN in studies from Asian countries, but not in those from European countries (p for subgroup difference = 0.001). Conclusion Elevated Lp(a) levels are associated DPN in T2D patients, particularly in studies from Asian countries. |
| format | Article |
| id | doaj-art-5d8dfb8cf5ef498b8c1e6ed11d32bf69 |
| institution | DOAJ |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-5d8dfb8cf5ef498b8c1e6ed11d32bf692025-08-20T03:05:45ZengBMCDiabetology & Metabolic Syndrome1758-59962025-03-0117111410.1186/s13098-025-01621-yAssociation between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysisLi Sheng0Yiwen Yang1Yunqing Zhou2Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou Hospital of Traditional Chinese MedicineDepartment of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou Hospital of Traditional Chinese MedicineDepartment of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou Hospital of Traditional Chinese MedicineAbstract Background Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes (T2D). Lipoprotein(a) [Lp(a)], a known cardiovascular risk factor, has been hypothesized to influence the development of DPN. This meta-analysis aimed to investigate the relationship between Lp(a) levels and DPN in patients with T2D. Methods Following PRISMA 2020 guidelines, a systematic search of PubMed, Embase, Web of Science, Wanfang, and CNKI databases was performed up to October 12, 2024. Observational studies assessing blood Lp(a) levels in T2D patients with and without DPN or evaluating the association between Lp(a) and DPN risk were included. Data synthesis utilized a random-effects model to calculate standardized mean differences (SMDs) and odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Results Eleven studies with 18,022 patients were included. Patients with DPN had significantly higher Lp(a) levels than those without DPN (SMD: 0.10, 95% CI: 0.02–0.19, p = 0.01; I² = 43%). High Lp(a) levels were associated with DPN (OR: 1.31, 95% CI: 1.07–1.60, p = 0.009; I² = 62%). Subgroup analyses according to study design, mean age of the patients, methods for measuring Lp(a) concentration, cutoff values of a high Lp(a), and study quality scores showed consistent results (p for subgroup difference all > 0.05). A high Lp(a) was associated with DPN in studies from Asian countries, but not in those from European countries (p for subgroup difference = 0.001). Conclusion Elevated Lp(a) levels are associated DPN in T2D patients, particularly in studies from Asian countries.https://doi.org/10.1186/s13098-025-01621-yLipoprotein(a)Diabetic peripheral neuropathyType 2 diabetesRisk factorMeta-analysis |
| spellingShingle | Li Sheng Yiwen Yang Yunqing Zhou Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis Diabetology & Metabolic Syndrome Lipoprotein(a) Diabetic peripheral neuropathy Type 2 diabetes Risk factor Meta-analysis |
| title | Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis |
| title_full | Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis |
| title_fullStr | Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis |
| title_full_unstemmed | Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis |
| title_short | Association between lipoprotein(a) and diabetic peripheral neuropathy in patients with type 2 diabetes: a meta-analysis |
| title_sort | association between lipoprotein a and diabetic peripheral neuropathy in patients with type 2 diabetes a meta analysis |
| topic | Lipoprotein(a) Diabetic peripheral neuropathy Type 2 diabetes Risk factor Meta-analysis |
| url | https://doi.org/10.1186/s13098-025-01621-y |
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