Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance
Abstract Plasmid copy number (PCN), the average number of plasmids per bacterial cell, links gene dosage to key traits such as host fitness, virulence, antibiotic resistance and evolutionary potential. Although often viewed as static, PCN is a dynamic, regulated trait responsive to environmental cue...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-025-00145-9 |
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| _version_ | 1849340955716485120 |
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| author | Helen Wang Enrique Joffré |
| author_facet | Helen Wang Enrique Joffré |
| author_sort | Helen Wang |
| collection | DOAJ |
| description | Abstract Plasmid copy number (PCN), the average number of plasmids per bacterial cell, links gene dosage to key traits such as host fitness, virulence, antibiotic resistance and evolutionary potential. Although often viewed as static, PCN is a dynamic, regulated trait responsive to environmental cues and selection pressures. This review examines the regulatory mechanisms controlling PCN and its impact on the trade-offs between bacterial fitness, virulence cost, and antibiotic resistance. |
| format | Article |
| id | doaj-art-5d89547a742c466183c9ea1d3dfbfccd |
| institution | Kabale University |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-5d89547a742c466183c9ea1d3dfbfccd2025-08-20T03:43:45ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-08-01311810.1038/s44259-025-00145-9Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistanceHelen Wang0Enrique Joffré1Department of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Medical Biochemistry and Microbiology, Uppsala UniversityAbstract Plasmid copy number (PCN), the average number of plasmids per bacterial cell, links gene dosage to key traits such as host fitness, virulence, antibiotic resistance and evolutionary potential. Although often viewed as static, PCN is a dynamic, regulated trait responsive to environmental cues and selection pressures. This review examines the regulatory mechanisms controlling PCN and its impact on the trade-offs between bacterial fitness, virulence cost, and antibiotic resistance.https://doi.org/10.1038/s44259-025-00145-9 |
| spellingShingle | Helen Wang Enrique Joffré Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance npj Antimicrobials and Resistance |
| title | Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance |
| title_full | Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance |
| title_fullStr | Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance |
| title_full_unstemmed | Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance |
| title_short | Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance |
| title_sort | plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance |
| url | https://doi.org/10.1038/s44259-025-00145-9 |
| work_keys_str_mv | AT helenwang plasmidcopynumberasamodulatorinbacterialpathogenesisandantibioticresistance AT enriquejoffre plasmidcopynumberasamodulatorinbacterialpathogenesisandantibioticresistance |