Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and Indanones
Abstract Compared to the methods that rely on complex and structurally unique substrates for the synthesis of heterocyclic compounds through intra‐ and intermolecular cyclization, strategies starting from simple and readily available substrates, combined with finely tuned catalytic system to achieve...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-03-01
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| Series: | ChemistryEurope |
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| Online Access: | https://doi.org/10.1002/ceur.202400105 |
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| author | Ren‐Rui Xu Chang‐Sheng Kuai Prof. Dr. Xiao‐Feng Wu |
| author_facet | Ren‐Rui Xu Chang‐Sheng Kuai Prof. Dr. Xiao‐Feng Wu |
| author_sort | Ren‐Rui Xu |
| collection | DOAJ |
| description | Abstract Compared to the methods that rely on complex and structurally unique substrates for the synthesis of heterocyclic compounds through intra‐ and intermolecular cyclization, strategies starting from simple and readily available substrates, combined with finely tuned catalytic system to achieve different chemoselectivity, offer significant advantages in terms of efficiency, cost‐effectiveness, and versatility. Herein, we present a palladium‐catalyzed carbonylation strategy that enables the selective and efficient synthesis of isoquinoline‐1,3(2H,4H)‐dione and indanone derivatives via distinct reaction pathways. Notably, the chemoselectivity was not determined by the differences in reactivity at the reaction sites but instead arises from the generation of distinct active palladium species under nearly identical reaction conditions, which subsequently react on the same reaction site but lead to different products. |
| format | Article |
| id | doaj-art-5d88555e48124bd99397f6d6f6a04ee0 |
| institution | OA Journals |
| issn | 2751-4765 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryEurope |
| spelling | doaj-art-5d88555e48124bd99397f6d6f6a04ee02025-08-20T01:57:59ZengWiley-VCHChemistryEurope2751-47652025-03-0132n/an/a10.1002/ceur.202400105Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and IndanonesRen‐Rui Xu0Chang‐Sheng Kuai1Prof. Dr. Xiao‐Feng Wu2Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning ChinaDalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning ChinaDalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning ChinaAbstract Compared to the methods that rely on complex and structurally unique substrates for the synthesis of heterocyclic compounds through intra‐ and intermolecular cyclization, strategies starting from simple and readily available substrates, combined with finely tuned catalytic system to achieve different chemoselectivity, offer significant advantages in terms of efficiency, cost‐effectiveness, and versatility. Herein, we present a palladium‐catalyzed carbonylation strategy that enables the selective and efficient synthesis of isoquinoline‐1,3(2H,4H)‐dione and indanone derivatives via distinct reaction pathways. Notably, the chemoselectivity was not determined by the differences in reactivity at the reaction sites but instead arises from the generation of distinct active palladium species under nearly identical reaction conditions, which subsequently react on the same reaction site but lead to different products.https://doi.org/10.1002/ceur.202400105Selectivity ControlPalladium CatalystCarbonylationHeterocycleDomino Reaction |
| spellingShingle | Ren‐Rui Xu Chang‐Sheng Kuai Prof. Dr. Xiao‐Feng Wu Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and Indanones ChemistryEurope Selectivity Control Palladium Catalyst Carbonylation Heterocycle Domino Reaction |
| title | Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and Indanones |
| title_full | Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and Indanones |
| title_fullStr | Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and Indanones |
| title_full_unstemmed | Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and Indanones |
| title_short | Palladium‐Catalyzed Selectivity Controlled Highly Efficient Carbonylative Synthesis of Isoquinoline‐1,3(2H,4H)‐diones and Indanones |
| title_sort | palladium catalyzed selectivity controlled highly efficient carbonylative synthesis of isoquinoline 1 3 2h 4h diones and indanones |
| topic | Selectivity Control Palladium Catalyst Carbonylation Heterocycle Domino Reaction |
| url | https://doi.org/10.1002/ceur.202400105 |
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