Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases
Abstract Objective To evaluate the reproducibility and effectiveness of the bone reporting and data system on CT (Bone‐RADS-CT) for incidental solitary bone lesions in adults. Materials and methods We retrospectively included 328 CT cases from three local and two public databases, respectively. All...
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SpringerOpen
2025-08-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-025-02057-8 |
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| author | Yue Xing Defang Ding Shun Dai Yangfan Hu Xianwei Liu Liangjing Lyu Guangcheng Zhang Shiqi Mao Qian Yin Junjie Lu Jiarui Yang Yang Song Huan Zhang Chengzhou Li Weiwu Yao Jingyu Zhong |
| author_facet | Yue Xing Defang Ding Shun Dai Yangfan Hu Xianwei Liu Liangjing Lyu Guangcheng Zhang Shiqi Mao Qian Yin Junjie Lu Jiarui Yang Yang Song Huan Zhang Chengzhou Li Weiwu Yao Jingyu Zhong |
| author_sort | Yue Xing |
| collection | DOAJ |
| description | Abstract Objective To evaluate the reproducibility and effectiveness of the bone reporting and data system on CT (Bone‐RADS-CT) for incidental solitary bone lesions in adults. Materials and methods We retrospectively included 328 CT cases from three local and two public databases, respectively. All the cases were histopathologically or clinically confirmed bone lesions, “do not touch” lesions with typical appearance, and remained stable for at least 2 years. Each lesion with gender, age, and clinical history was categorized according to the Bone-RADS algorithm by two musculoskeletal radiologists and two non-musculoskeletal radiologists. The Bone-RADS categories were as follows: Bone-RADS-1, likely benign, leave alone; Bone-RADS-2, incomplete assessed on imaging, perform different imaging modality; Bone-RADS-3, intermediate, perform follow-up imaging; Bone-RADS-4, suspicious for malignancy or need for treatment, biopsy and/or oncologic referral. Inter-reader agreement was evaluated. The diagnostic performance of the Bone-RADS-CT for distinguishing positive cases (intermediate or malignant lesions or osteomyelitis) from negative cases (benign lesions), were measured, using histopathology results, clinical diagnosis, or follow-up as a standard reference. Results There were 223 positive cases and 105 negative cases, respectively. The overall inter-reader agreement between two musculoskeletal and two non-musculoskeletal radiologists were both moderate (weighted kappa 0.553 and 0.403). The diagnostic performance for identifying intermediate or malignant lesions or osteomyelitis ranged according to radiologists with sensitivities of 88.8% to 94.6%, specificities of 42.9% to 71.1%, and accuracies of 78.0% to 86.6%. Conclusion Bone-RADS-CT is effective for identifying bone lesions that need further treatment, but is only moderately reliable for readers of different specialties and experience. Critical relevance statement Bone-RADS-CT has been demonstrated to be a reliable algorithm for non-musculoskeletal radiologists and an effective tool for identifying the “need for treatment” incidental solitary bone lesions in adults, but still needs improvement in the rating method and category definition. Key Points Bone-RADS-CT has been demonstrated to be reliable and accurate when rated by musculoskeletal radiologists. Bone-RADS-CT achieved moderate agreement for musculoskeletal and non-musculoskeletal radiologists. Bone-RADS-CT presented high sensitivities but low specificities for identifying “need for treatment” bone lesions. Graphical Abstract |
| format | Article |
| id | doaj-art-5d836ecf25b9406b8b121d70b0fe90f8 |
| institution | Kabale University |
| issn | 1869-4101 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
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| series | Insights into Imaging |
| spelling | doaj-art-5d836ecf25b9406b8b121d70b0fe90f82025-08-20T03:42:49ZengSpringerOpenInsights into Imaging1869-41012025-08-0116111010.1186/s13244-025-02057-8Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databasesYue Xing0Defang Ding1Shun Dai2Yangfan Hu3Xianwei Liu4Liangjing Lyu5Guangcheng Zhang6Shiqi Mao7Qian Yin8Junjie Lu9Jiarui Yang10Yang Song11Huan Zhang12Chengzhou Li13Weiwu Yao14Jingyu Zhong15Department of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Orthopedics, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Pathology, Renhe HospitalDepartment of Epidemiology and Population Health, Stanford University School of MedicineDepartment of Biomedical Engineering, Boston UniversityMR Research Collaboration Team, Siemens Healthineers Ltd.Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Nuclear Medicine, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Imaging, Tongren Hospital, Shanghai Jiao Tong University School of MedicineAbstract Objective To evaluate the reproducibility and effectiveness of the bone reporting and data system on CT (Bone‐RADS-CT) for incidental solitary bone lesions in adults. Materials and methods We retrospectively included 328 CT cases from three local and two public databases, respectively. All the cases were histopathologically or clinically confirmed bone lesions, “do not touch” lesions with typical appearance, and remained stable for at least 2 years. Each lesion with gender, age, and clinical history was categorized according to the Bone-RADS algorithm by two musculoskeletal radiologists and two non-musculoskeletal radiologists. The Bone-RADS categories were as follows: Bone-RADS-1, likely benign, leave alone; Bone-RADS-2, incomplete assessed on imaging, perform different imaging modality; Bone-RADS-3, intermediate, perform follow-up imaging; Bone-RADS-4, suspicious for malignancy or need for treatment, biopsy and/or oncologic referral. Inter-reader agreement was evaluated. The diagnostic performance of the Bone-RADS-CT for distinguishing positive cases (intermediate or malignant lesions or osteomyelitis) from negative cases (benign lesions), were measured, using histopathology results, clinical diagnosis, or follow-up as a standard reference. Results There were 223 positive cases and 105 negative cases, respectively. The overall inter-reader agreement between two musculoskeletal and two non-musculoskeletal radiologists were both moderate (weighted kappa 0.553 and 0.403). The diagnostic performance for identifying intermediate or malignant lesions or osteomyelitis ranged according to radiologists with sensitivities of 88.8% to 94.6%, specificities of 42.9% to 71.1%, and accuracies of 78.0% to 86.6%. Conclusion Bone-RADS-CT is effective for identifying bone lesions that need further treatment, but is only moderately reliable for readers of different specialties and experience. Critical relevance statement Bone-RADS-CT has been demonstrated to be a reliable algorithm for non-musculoskeletal radiologists and an effective tool for identifying the “need for treatment” incidental solitary bone lesions in adults, but still needs improvement in the rating method and category definition. Key Points Bone-RADS-CT has been demonstrated to be reliable and accurate when rated by musculoskeletal radiologists. Bone-RADS-CT achieved moderate agreement for musculoskeletal and non-musculoskeletal radiologists. Bone-RADS-CT presented high sensitivities but low specificities for identifying “need for treatment” bone lesions. Graphical Abstracthttps://doi.org/10.1186/s13244-025-02057-8Bone neoplasmsClinical decision-makingReproducibility of resultsMultidetector computed tomography |
| spellingShingle | Yue Xing Defang Ding Shun Dai Yangfan Hu Xianwei Liu Liangjing Lyu Guangcheng Zhang Shiqi Mao Qian Yin Junjie Lu Jiarui Yang Yang Song Huan Zhang Chengzhou Li Weiwu Yao Jingyu Zhong Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases Insights into Imaging Bone neoplasms Clinical decision-making Reproducibility of results Multidetector computed tomography |
| title | Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases |
| title_full | Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases |
| title_fullStr | Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases |
| title_full_unstemmed | Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases |
| title_short | Bone reporting and data system on CT (Bone-RADS-CT): a validation study by four readers on 328 cases from three local and two public databases |
| title_sort | bone reporting and data system on ct bone rads ct a validation study by four readers on 328 cases from three local and two public databases |
| topic | Bone neoplasms Clinical decision-making Reproducibility of results Multidetector computed tomography |
| url | https://doi.org/10.1186/s13244-025-02057-8 |
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