Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical Storm
Cardiac amyloidosis is a condition when amyloid fibers are deposited in the extracellular space of the heart causing tachyarrhythmias, heart failure, or sudden cardiac death. We present a 71-year-old woman presenting with dyspnea on admission. Echocardiogram revealed diastolic heart failure and left...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/3293728 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546061214810112 |
|---|---|
| author | Adithya T. Mathews Abu-Sayeef Mirza Chandrashekar Bohra Akshay G. Mathews Philip Ritucci-Chinni Jamie L. Weber William W. Bulkeley Maqsood Siddique David Whitaker Richard Bowerman |
| author_facet | Adithya T. Mathews Abu-Sayeef Mirza Chandrashekar Bohra Akshay G. Mathews Philip Ritucci-Chinni Jamie L. Weber William W. Bulkeley Maqsood Siddique David Whitaker Richard Bowerman |
| author_sort | Adithya T. Mathews |
| collection | DOAJ |
| description | Cardiac amyloidosis is a condition when amyloid fibers are deposited in the extracellular space of the heart causing tachyarrhythmias, heart failure, or sudden cardiac death. We present a 71-year-old woman presenting with dyspnea on admission. Echocardiogram revealed diastolic heart failure and left ventricular hypertrophy with strain pattern concerning for an infiltrative process. She was discharged with diuretic therapy and scheduled for a cardiac magnetic resonance imaging. One week after discharge, she was readmitted with progressive shortness of breath and syncope. She was found to be in shock and had multiple episodes of cardiac arrest with both ventricular tachycardia and pulseless electrical activity. She developed electrical storm and eventually passed within 24 hours. Autopsy revealed gross cardiomegaly and left ventricular hypertrophy with Congo red staining revealing amyloid fibrils with apple-green birefringence. This case demonstrates the rapid progression of cardiac amyloidosis from acute-onset diastolic heart failure to uncontrollable ventricular tachycardia, and eventually death. We review the literature regarding multiple diagnostic modalities that facilitate the confirmation of cardiac amyloidosis. |
| format | Article |
| id | doaj-art-5d80582f862442acaaf7798700bd8eab |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-5d80582f862442acaaf7798700bd8eab2025-02-03T07:24:00ZengWileyCase Reports in Medicine1687-96271687-96352021-01-01202110.1155/2021/32937283293728Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical StormAdithya T. Mathews0Abu-Sayeef Mirza1Chandrashekar Bohra2Akshay G. Mathews3Philip Ritucci-Chinni4Jamie L. Weber5William W. Bulkeley6Maqsood Siddique7David Whitaker8Richard Bowerman9Department of Internal Medicine, University of South Florida, Tampa, FL, USADepartment of Internal Medicine, University of South Florida, Tampa, FL, USADepartment of Internal Medicine, University of South Florida, Tampa, FL, USAUniversity of South Florida, Tampa, FL, USADepartment of Internal Medicine, University of South Florida, Tampa, FL, USADepartment of Internal Medicine, University of South Florida, Tampa, FL, USADepartment of Pathology, James A Haley Veteran Affairs Hospital, Tampa, FL, USADepartment of Cardiology, James A Haley Veteran Affairs Hospital, Tampa, FL, USADepartment of Cardiology, James A Haley Veteran Affairs Hospital, Tampa, FL, USADepartment of Cardiology, James A Haley Veteran Affairs Hospital, Tampa, FL, USACardiac amyloidosis is a condition when amyloid fibers are deposited in the extracellular space of the heart causing tachyarrhythmias, heart failure, or sudden cardiac death. We present a 71-year-old woman presenting with dyspnea on admission. Echocardiogram revealed diastolic heart failure and left ventricular hypertrophy with strain pattern concerning for an infiltrative process. She was discharged with diuretic therapy and scheduled for a cardiac magnetic resonance imaging. One week after discharge, she was readmitted with progressive shortness of breath and syncope. She was found to be in shock and had multiple episodes of cardiac arrest with both ventricular tachycardia and pulseless electrical activity. She developed electrical storm and eventually passed within 24 hours. Autopsy revealed gross cardiomegaly and left ventricular hypertrophy with Congo red staining revealing amyloid fibrils with apple-green birefringence. This case demonstrates the rapid progression of cardiac amyloidosis from acute-onset diastolic heart failure to uncontrollable ventricular tachycardia, and eventually death. We review the literature regarding multiple diagnostic modalities that facilitate the confirmation of cardiac amyloidosis.http://dx.doi.org/10.1155/2021/3293728 |
| spellingShingle | Adithya T. Mathews Abu-Sayeef Mirza Chandrashekar Bohra Akshay G. Mathews Philip Ritucci-Chinni Jamie L. Weber William W. Bulkeley Maqsood Siddique David Whitaker Richard Bowerman Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical Storm Case Reports in Medicine |
| title | Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical Storm |
| title_full | Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical Storm |
| title_fullStr | Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical Storm |
| title_full_unstemmed | Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical Storm |
| title_short | Diagnosing Cardiac Amyloidosis: From Heart Failure to Electrical Storm |
| title_sort | diagnosing cardiac amyloidosis from heart failure to electrical storm |
| url | http://dx.doi.org/10.1155/2021/3293728 |
| work_keys_str_mv | AT adithyatmathews diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT abusayeefmirza diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT chandrashekarbohra diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT akshaygmathews diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT philiprituccichinni diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT jamielweber diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT williamwbulkeley diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT maqsoodsiddique diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT davidwhitaker diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm AT richardbowerman diagnosingcardiacamyloidosisfromheartfailuretoelectricalstorm |