Ameliorative Effect of Itaconic Acid/IRG1 Against Endoplasmic Reticulum Stress-Induced Necroptosis in Granulosa Cells via PERK-ATF4-AChE Pathway in Bovine

Ameliorative Effect of Itaconic Acid/IRG1 Against Endoplasmic Reticulum Stress-Induced Necroptosis in Granulosa Cells via PERK-ATF4-AChE Pathway in Bovine

The necroptosis of granulosa cells has been proven to be one of the important triggers of follicular atresia, which is an important cause of reduced reproductive capacity in cows. The rapid growth of granulosa cells is accompanied by endoplasmic reticulum stress (ERS), leading to granulosa cell deat...

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Bibliographic Details
Main Authors: Xiaorui Yang, Yue Chen, Xinzi Wang, Gaoqing Xu, Hongjie Wang, Xinqi Shu, He Ding, Xin Ma, Jing Guo, Jun Wang, Jing Zhao, Yi Fang, Hongyu Liu, Wenfa Lu
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
itaconic acid
ERS
granulosa cells
necroptosis
Online Access:https://www.mdpi.com/2073-4409/14/6/419
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