Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry
A reliable synthetic method based on the already known Blanc–Quelet methodology has been developed for upgrading bio-based phenols into valuable electrophilic mono-, di-, and trifunctional benzyl chlorides. These compounds show significant potential as building blocks for polymer production and the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/15/14/7876 |
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| author | Nicola Porcelli Biagio Anderlini Alberto Ughetti Mattia Giuliana Matteo Fiocchi Fabrizio Roncaglia |
| author_facet | Nicola Porcelli Biagio Anderlini Alberto Ughetti Mattia Giuliana Matteo Fiocchi Fabrizio Roncaglia |
| author_sort | Nicola Porcelli |
| collection | DOAJ |
| description | A reliable synthetic method based on the already known Blanc–Quelet methodology has been developed for upgrading bio-based phenols into valuable electrophilic mono-, di-, and trifunctional benzyl chlorides. These compounds show significant potential as building blocks for polymer production and the synthesis of specialty chemicals. As an example of their applicability, their direct interaction with formamide has been evaluated, obtaining an effective transformation towards the corresponding <i>N</i>-formylamides. These compounds represent versatile synthetic precursors to a variety of functionalized targets. |
| format | Article |
| id | doaj-art-5d6153e7d28f48779c23d17b970f1bbc |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-5d6153e7d28f48779c23d17b970f1bbc2025-08-20T03:58:30ZengMDPI AGApplied Sciences2076-34172025-07-011514787610.3390/app15147876Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical IndustryNicola Porcelli0Biagio Anderlini1Alberto Ughetti2Mattia Giuliana3Matteo Fiocchi4Fabrizio Roncaglia5Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, ItalyDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, ItalyDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, ItalyDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, ItalyDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, ItalyDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, ItalyA reliable synthetic method based on the already known Blanc–Quelet methodology has been developed for upgrading bio-based phenols into valuable electrophilic mono-, di-, and trifunctional benzyl chlorides. These compounds show significant potential as building blocks for polymer production and the synthesis of specialty chemicals. As an example of their applicability, their direct interaction with formamide has been evaluated, obtaining an effective transformation towards the corresponding <i>N</i>-formylamides. These compounds represent versatile synthetic precursors to a variety of functionalized targets.https://www.mdpi.com/2076-3417/15/14/7876biobased phenolicsBlanc–Queletbenzyl chloridesbenzyl formamides |
| spellingShingle | Nicola Porcelli Biagio Anderlini Alberto Ughetti Mattia Giuliana Matteo Fiocchi Fabrizio Roncaglia Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry Applied Sciences biobased phenolics Blanc–Quelet benzyl chlorides benzyl formamides |
| title | Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry |
| title_full | Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry |
| title_fullStr | Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry |
| title_full_unstemmed | Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry |
| title_short | Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry |
| title_sort | upgrading renewable phenols to functional benzyl chlorides and formamides versatile building blocks for the chemical industry |
| topic | biobased phenolics Blanc–Quelet benzyl chlorides benzyl formamides |
| url | https://www.mdpi.com/2076-3417/15/14/7876 |
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