Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass)
The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/245828 |
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| author | Eduardo Padilla-Camberos Moisés Martínez-Velázquez José Miguel Flores-Fernández Socorro Villanueva-Rodríguez |
| author_facet | Eduardo Padilla-Camberos Moisés Martínez-Velázquez José Miguel Flores-Fernández Socorro Villanueva-Rodríguez |
| author_sort | Eduardo Padilla-Camberos |
| collection | DOAJ |
| description | The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana was evaluated with respect to its genotoxic potential through micronucleus assay in rodents. The frequency of micronuclei in groups of animals treated with avocado seed extract showed no differences compared to the negative control (vehicle); therefore, it is considered that the avocado seed extract showed no genotoxic activity in the micronucleus test. |
| format | Article |
| id | doaj-art-5d5eabd4b6194de0999d4d1a2c49ad2d |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5d5eabd4b6194de0999d4d1a2c49ad2d2025-02-03T01:10:59ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/245828245828Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass)Eduardo Padilla-Camberos0Moisés Martínez-Velázquez1José Miguel Flores-Fernández2Socorro Villanueva-Rodríguez3Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Avenida Normalistas 800, Colonia Colinas de la Normal, Guadalajara 44270, JAL, MexicoCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Avenida Normalistas 800, Colonia Colinas de la Normal, Guadalajara 44270, JAL, MexicoCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Avenida Normalistas 800, Colonia Colinas de la Normal, Guadalajara 44270, JAL, MexicoCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Avenida Normalistas 800, Colonia Colinas de la Normal, Guadalajara 44270, JAL, MexicoThe use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana was evaluated with respect to its genotoxic potential through micronucleus assay in rodents. The frequency of micronuclei in groups of animals treated with avocado seed extract showed no differences compared to the negative control (vehicle); therefore, it is considered that the avocado seed extract showed no genotoxic activity in the micronucleus test.http://dx.doi.org/10.1155/2013/245828 |
| spellingShingle | Eduardo Padilla-Camberos Moisés Martínez-Velázquez José Miguel Flores-Fernández Socorro Villanueva-Rodríguez Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass) The Scientific World Journal |
| title | Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass) |
| title_full | Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass) |
| title_fullStr | Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass) |
| title_full_unstemmed | Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass) |
| title_short | Acute Toxicity and Genotoxic Activity of Avocado Seed Extract (Persea americana Mill., c.v. Hass) |
| title_sort | acute toxicity and genotoxic activity of avocado seed extract persea americana mill c v hass |
| url | http://dx.doi.org/10.1155/2013/245828 |
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