Radioisotope synovectomy in the treatment of patients with rheumatoid arthritis
In a number of cases, systemic therapy for rheumatoid arthritis (RA), including disease-modifying anti-rheumatic drugs, biological agents, glucocorticoids (GCs), and nonsteroidal anti-inflammatory drugs, fails to completely suppress joint inflammatory changes in the patients. Therefore, local method...
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IMA-PRESS LLC
2019-03-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/894 |
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| author | R. M. Balabanova Yu. A. Olyunin A. M. Lila |
| author_facet | R. M. Balabanova Yu. A. Olyunin A. M. Lila |
| author_sort | R. M. Balabanova |
| collection | DOAJ |
| description | In a number of cases, systemic therapy for rheumatoid arthritis (RA), including disease-modifying anti-rheumatic drugs, biological agents, glucocorticoids (GCs), and nonsteroidal anti-inflammatory drugs, fails to completely suppress joint inflammatory changes in the patients. Therefore, local methods are widely used in the combination therapy of RA. Intra-articular injection of hyaluronic acid (HA) is a highly local treatment modality. HA can be used as initial therapy when it is necessary to achieve rapid clinical improvement, or at a later stage of the disease, in exacerbation of arthritis. However, in some patients the effect of intra-articular HA can be short-lasting, and a favorable result can be obtained with local radiotherapy. It is based on powerful irradiation of the inflamed synovium, which is provided by intra-articular injection of radioactive isotope colloids. In Russia, RA was successfully treated with colloidal Au-198, but its production was ceased in the 1990s, and agents for radioisotope synovectomy have been long unavailable.Tungsten-188/Rhenium-188generator has been recently designed in Russia, which allows Rhenium-188 to be obtained in clinics. Preclinical trials have shown that intra-articular injection ensures good fixation of the drug in the knee joint with its insignificant accumulation in the liver and other non-target organs and tissues. Introduction of this drug into routine clinical practice can markedly improve the efficiency of treatment in patients with chronic arthritis. |
| format | Article |
| id | doaj-art-5d5d2f24e59e498b8e904bc7ee22a20f |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | IMA-PRESS LLC |
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| series | Современная ревматология |
| spelling | doaj-art-5d5d2f24e59e498b8e904bc7ee22a20f2025-08-20T03:20:59ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2019-03-0113110110710.14412/1996-7012-2019-1-101-1072155Radioisotope synovectomy in the treatment of patients with rheumatoid arthritisR. M. Balabanova0Yu. A. Olyunin1A. M. Lila2V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyIn a number of cases, systemic therapy for rheumatoid arthritis (RA), including disease-modifying anti-rheumatic drugs, biological agents, glucocorticoids (GCs), and nonsteroidal anti-inflammatory drugs, fails to completely suppress joint inflammatory changes in the patients. Therefore, local methods are widely used in the combination therapy of RA. Intra-articular injection of hyaluronic acid (HA) is a highly local treatment modality. HA can be used as initial therapy when it is necessary to achieve rapid clinical improvement, or at a later stage of the disease, in exacerbation of arthritis. However, in some patients the effect of intra-articular HA can be short-lasting, and a favorable result can be obtained with local radiotherapy. It is based on powerful irradiation of the inflamed synovium, which is provided by intra-articular injection of radioactive isotope colloids. In Russia, RA was successfully treated with colloidal Au-198, but its production was ceased in the 1990s, and agents for radioisotope synovectomy have been long unavailable.Tungsten-188/Rhenium-188generator has been recently designed in Russia, which allows Rhenium-188 to be obtained in clinics. Preclinical trials have shown that intra-articular injection ensures good fixation of the drug in the knee joint with its insignificant accumulation in the liver and other non-target organs and tissues. Introduction of this drug into routine clinical practice can markedly improve the efficiency of treatment in patients with chronic arthritis.https://mrj.ima-press.net/mrj/article/view/894rheumatoid arthritislocal radiotherapyradioisotope synovectomyradiocolloidsynovium |
| spellingShingle | R. M. Balabanova Yu. A. Olyunin A. M. Lila Radioisotope synovectomy in the treatment of patients with rheumatoid arthritis Современная ревматология rheumatoid arthritis local radiotherapy radioisotope synovectomy radiocolloid synovium |
| title | Radioisotope synovectomy in the treatment of patients with rheumatoid arthritis |
| title_full | Radioisotope synovectomy in the treatment of patients with rheumatoid arthritis |
| title_fullStr | Radioisotope synovectomy in the treatment of patients with rheumatoid arthritis |
| title_full_unstemmed | Radioisotope synovectomy in the treatment of patients with rheumatoid arthritis |
| title_short | Radioisotope synovectomy in the treatment of patients with rheumatoid arthritis |
| title_sort | radioisotope synovectomy in the treatment of patients with rheumatoid arthritis |
| topic | rheumatoid arthritis local radiotherapy radioisotope synovectomy radiocolloid synovium |
| url | https://mrj.ima-press.net/mrj/article/view/894 |
| work_keys_str_mv | AT rmbalabanova radioisotopesynovectomyinthetreatmentofpatientswithrheumatoidarthritis AT yuaolyunin radioisotopesynovectomyinthetreatmentofpatientswithrheumatoidarthritis AT amlila radioisotopesynovectomyinthetreatmentofpatientswithrheumatoidarthritis |