AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p/FOXP1

AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p/FOXP1

Abstract Background Endothelial dysfunction is a pivotal contributor to cardiovascular complications in individuals with diabetes. However, the precise role of macrophages and their exosomes in the diabetic milieu remains elusive. Methods Exosomes (Exos) were isolated from the supernatants of macrop...

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Bibliographic Details
Main Authors: Yang Ji, Huanzhen Chen, Lihua Pang, Changnong Chen, Sha Wang, Jing Chen, Lei Fang, Benrong Liu, Yongruo Cheng, Shiming Liu, Yun Zhong
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cardiovascular Diabetology
Subjects:
Endotheliocytes
Macrophage
Exosomes
microRNAs
Diabetes
Inflammation
Online Access:https://doi.org/10.1186/s12933-025-02715-7
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