Fat-cartilage axis: the regulation of IL-6/Osteopontin signaling in osteoarthritis of mice

Abstract The infrapatellar fat pad (IPFP) acts as a bioactive reservoir, secreting proinflammatory cytokines that orchestrate both local and systemic inflammatory cascades. Despite its emerging role in knee osteoarthritis (OA) pathophysiology, the molecular and cellular mechanisms driving IPFP-media...

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Bibliographic Details
Main Authors: Bing-yang Dai, Zhong-lian Huang, Ming-gui Bao, Hong-jiang Chen, Xiao-hui Lu, Jun Hu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02622-6
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