Fungal keratitis with topical interferon-α2b in ocular surface squamous neoplasia
This report highlights a unique case of fungal keratitis following the use of topical interferon alpha-2b (IFN-α2b) for managing ocular surface squamous neoplasia (OSSN). We describe the clinical journey of a 55-year-old male with OSSN treated with topical IFN-α2b, resulting in fungal keratitis. The...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Clinical Ophthalmology and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_223_24 |
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| Summary: | This report highlights a unique case of fungal keratitis following the use of topical interferon alpha-2b (IFN-α2b) for managing ocular surface squamous neoplasia (OSSN). We describe the clinical journey of a 55-year-old male with OSSN treated with topical IFN-α2b, resulting in fungal keratitis. The initial surgical recommendation was declined, leading to interferon therapy and subsequent development of keratitis, managed through therapeutic penetrating keratoplasty. Postsurgery, the patient showed no OSSN recurrence, with a clear graft and confirmed mild squamous dysplasia with atypia on histopathology. This case suggests a potential risk of microbial keratitis, possibly due to local immune suppression, following topical IFN-α2b treatment for OSSN, underscoring the need for cautious monitoring. |
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| ISSN: | 2320-3897 2320-3900 |