The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep
According to statistics, more than one-third of the global population currently experiences sleep problems, and about 10% of adults have been diagnosed with insomnia, a proportion that is increasing annually. Most currently used insomnia medications are not specifically developed but are discovered...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/4954030 |
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| _version_ | 1849339699714326528 |
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| author | Wenwen Zhu Ailin Gong Bin Zhang Hanxing Cheng Lishan Huang Xiao Wu Dechou Zhang Wenbin Dai Sen Li Houping Xu |
| author_facet | Wenwen Zhu Ailin Gong Bin Zhang Hanxing Cheng Lishan Huang Xiao Wu Dechou Zhang Wenbin Dai Sen Li Houping Xu |
| author_sort | Wenwen Zhu |
| collection | DOAJ |
| description | According to statistics, more than one-third of the global population currently experiences sleep problems, and about 10% of adults have been diagnosed with insomnia, a proportion that is increasing annually. Most currently used insomnia medications are not specifically developed but are discovered by chance, often resulting in unavoidable side effects like addiction. Thus, there is an urgent need to find safer and more effective therapeutic options. Resveratrol, a natural polyphenolic compound, shows significant potential in improving insomnia. Research shows that its effects may be achieved through multiple biological processes, including antiapoptosis, antioxidant activity, anti-inflammation, circadian rhythm regulation, modulation of neurotransmitters (gamma-aminobutyric acid (GABA), DA, 5-HT, cortisol), and increased levels of neurotrophic factor BDNF. Additionally, resveratrol’s treatment of insomnia is closely linked to the SIRT1, AMPK, NF-κB, mTOR, PI3K/Akt, and MAPK pathways. This review summarizes the mechanisms of resveratrol in treating insomnia to provide researchers with a deeper understanding of its action, which can aid in the development of novel targeted drugs and offer innovative ideas and methods for clinical insomnia treatment. |
| format | Article |
| id | doaj-art-5d49861de4cf4849b2c832a8bfff8776 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5d49861de4cf4849b2c832a8bfff87762025-08-20T03:44:04ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/4954030The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving SleepWenwen Zhu0Ailin Gong1Bin Zhang2Hanxing Cheng3Lishan Huang4Xiao Wu5Dechou Zhang6Wenbin Dai7Sen Li8Houping Xu9Geriatric DepartmentGeriatric DepartmentGeriatric DepartmentGeriatric DepartmentGeriatric DepartmentDepartment of Acupuncture and TuinaDepartment of Acupuncture and TuinaDepartment of Respiratory medicineDivision of Spine SurgeryGeriatric DepartmentAccording to statistics, more than one-third of the global population currently experiences sleep problems, and about 10% of adults have been diagnosed with insomnia, a proportion that is increasing annually. Most currently used insomnia medications are not specifically developed but are discovered by chance, often resulting in unavoidable side effects like addiction. Thus, there is an urgent need to find safer and more effective therapeutic options. Resveratrol, a natural polyphenolic compound, shows significant potential in improving insomnia. Research shows that its effects may be achieved through multiple biological processes, including antiapoptosis, antioxidant activity, anti-inflammation, circadian rhythm regulation, modulation of neurotransmitters (gamma-aminobutyric acid (GABA), DA, 5-HT, cortisol), and increased levels of neurotrophic factor BDNF. Additionally, resveratrol’s treatment of insomnia is closely linked to the SIRT1, AMPK, NF-κB, mTOR, PI3K/Akt, and MAPK pathways. This review summarizes the mechanisms of resveratrol in treating insomnia to provide researchers with a deeper understanding of its action, which can aid in the development of novel targeted drugs and offer innovative ideas and methods for clinical insomnia treatment.http://dx.doi.org/10.1155/mi/4954030 |
| spellingShingle | Wenwen Zhu Ailin Gong Bin Zhang Hanxing Cheng Lishan Huang Xiao Wu Dechou Zhang Wenbin Dai Sen Li Houping Xu The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep Mediators of Inflammation |
| title | The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep |
| title_full | The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep |
| title_fullStr | The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep |
| title_full_unstemmed | The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep |
| title_short | The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep |
| title_sort | chronobiological and neuroprotective mechanisms of resveratrol in improving sleep |
| url | http://dx.doi.org/10.1155/mi/4954030 |
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