MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis

MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis

Abstract Murine double minute 2 (MDM2) inhibitors have shown promising activity in TP53-wild type tumors and are under active investigation across a spectrum of malignancies. Herein, we report a 51-year-old female with MDM2-amplified, TP53-wild type adenoid cystic carcinoma who was treated with a MD...

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Bibliographic Details
Main Authors: Vishesh Khanna, Gohar Eslami, Rochelle Reyes, Robert Diep, Sebastian Fernandez-Pol, Henning Stehr, Carlos Jose Suarez, Harlan Pinto, James M. Ford, Tian Yi Zhang, Christopher T. Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00823-x
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