CloseRead: a tool for assessing assembly errors in immunoglobulin loci applied to vertebrate long-read genome assemblies

Abstract Despite tremendous advances in long-read sequencing, some structurally complex and repeat-rich genomic regions remain challenging to assemble. Furthermore, we lack tools to assess local assembly quality, making it hard to identify problems and assess progress. Here we develop a new approach...

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Bibliographic Details
Main Authors: Yixin Zhu, Corey Watson, Yana Safonova, Matt Pennell, Anton Bankevich
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03594-7
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