Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility
Abstract Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202417528 |
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| author | Yangshuo Li Wei Zhou Jie Ding Di Song Wen Cheng Jin Yu Shuai Sun Shanshan Mei Xiaolan Liang Qianqian Zhao Yanping Kuang Mingqing Li Zhexin Ni Chaoqin Yu Yue Gao |
| author_facet | Yangshuo Li Wei Zhou Jie Ding Di Song Wen Cheng Jin Yu Shuai Sun Shanshan Mei Xiaolan Liang Qianqian Zhao Yanping Kuang Mingqing Li Zhexin Ni Chaoqin Yu Yue Gao |
| author_sort | Yangshuo Li |
| collection | DOAJ |
| description | Abstract Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE‐associated infertility (OEI). A single‐cell atlas of pre‐ovulatory follicular fluid from OEI patients reveals dynamic changes in iron metabolism and iron‐induced senescence phenotypes. Spatial transcriptomics using Stereo‐seq in iron‐overloaded mouse ovaries further identifies localized senescence features. Additional analysis of aging human ovaries highlights conserved patterns of iron dysregulation. These findings provide mechanistic insight into iron overload‐related ovarian pathology and suggest potential therapeutic targets for improving oocyte quality in OEI. |
| format | Article |
| id | doaj-art-5d41a4f4933f45d89b15c3e183869a54 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-5d41a4f4933f45d89b15c3e183869a542025-08-20T03:41:08ZengWileyAdvanced Science2198-38442025-08-011229n/an/a10.1002/advs.202417528Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated InfertilityYangshuo Li0Wei Zhou1Jie Ding2Di Song3Wen Cheng4Jin Yu5Shuai Sun6Shanshan Mei7Xiaolan Liang8Qianqian Zhao9Yanping Kuang10Mingqing Li11Zhexin Ni12Chaoqin Yu13Yue Gao14Department of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaBeijing Institute of Radiation MedicineBeijing 100850 ChinaDepartment of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaDepartment of Assisted Reproduction the First Affiliated Hospital of Naval Medical University Shanghai 200433 ChinaDepartment of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaDepartment of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaDepartment of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaDepartment of Gynecology and Obstetrics The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou Zhejiang Province 310006 ChinaDepartment of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaDepartment of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaDepartment of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 ChinaDepartment of Reproductive Immunology The International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 ChinaBeijing Institute of Radiation MedicineBeijing 100850 ChinaDepartment of Traditional Chinese Gynecology the First Affiliated Hospital of Naval Military Medical University Shanghai 200433 ChinaBeijing Institute of Radiation MedicineBeijing 100850 ChinaAbstract Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE‐associated infertility (OEI). A single‐cell atlas of pre‐ovulatory follicular fluid from OEI patients reveals dynamic changes in iron metabolism and iron‐induced senescence phenotypes. Spatial transcriptomics using Stereo‐seq in iron‐overloaded mouse ovaries further identifies localized senescence features. Additional analysis of aging human ovaries highlights conserved patterns of iron dysregulation. These findings provide mechanistic insight into iron overload‐related ovarian pathology and suggest potential therapeutic targets for improving oocyte quality in OEI.https://doi.org/10.1002/advs.202417528endometriosisinfertilityironmulti‐omicssenescence |
| spellingShingle | Yangshuo Li Wei Zhou Jie Ding Di Song Wen Cheng Jin Yu Shuai Sun Shanshan Mei Xiaolan Liang Qianqian Zhao Yanping Kuang Mingqing Li Zhexin Ni Chaoqin Yu Yue Gao Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility Advanced Science endometriosis infertility iron multi‐omics senescence |
| title | Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility |
| title_full | Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility |
| title_fullStr | Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility |
| title_full_unstemmed | Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility |
| title_short | Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility |
| title_sort | integrative single cell analysis reveals iron overload induced senescence and metabolic reprogramming in ovarian endometriosis associated infertility |
| topic | endometriosis infertility iron multi‐omics senescence |
| url | https://doi.org/10.1002/advs.202417528 |
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