Lung cancer-associated fibroblasts-mediated collagen deposition drives mediastinal lymph node metastasis in non-small cell lung cancer

Lung cancer-associated fibroblasts-mediated collagen deposition drives mediastinal lymph node metastasis in non-small cell lung cancer

IntroductionMetastasis to mediastinal lymph nodes signifies an advanced stage of non-small cell lung cancer (NSCLC) and presents significant clinical challenges. Cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) play a crucial role in tumor progression by promoting growth...

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Bibliographic Details
Main Authors:	Caoyang Chen, Yuqian Feng, Frankie Chi Fat Ko, Sze Kwan Lam, Sheng Yan, James Chung Man Ho
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Oncology
Subjects:	cancer-associated fibroblasts lymphangiogenesis mediastinal lymph node metastasis NSCLC orthotopic xenograft model
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1597585/full
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