A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods

A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods

There is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for predicting local respiratory effects from inhalation exposure to irritants. The current study introduces a concept for applying in vitro and in...

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Bibliographic Details
Main Authors: Nikaeta Sadekar, Holger Peter Behrsing, Tanja Hansen, Vivek Patel, Hazel Paulo, Alex Rae, Detlef Ritter, Katharina Schwarz, Anne Marie Api
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Toxics
Subjects:
in vitro
in silico
exposure assessment
safety assessment
inhalation
threshold of toxicological concern
Online Access:https://www.mdpi.com/2305-6304/13/1/35
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