TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes

TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes

Abstract Background TGF-β-activated kinase 1 binding protein 2 (TAB2) is an intermediary protein that links Tumor necrosis factor receptor 1 (TNFR1) and other receptor signals to the TGF-β-activated kinase 1 (TAK1) signaling complex. TAB2 frameshift mutations have been linked to dilated cardiomyopat...

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Bibliographic Details
Main Authors: Wenrui Sun, Jianchao Zhang, Shuang Li, Wanrong Fu, Yangyang Liu, Mengduan Liu, Jianzeng Dong, Xiaoyan Zhao, Xiaowei Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
TAB2 knockout
IPSCs
Dilated cardiomyopathy
Mitochondrial calcium overload
Online Access:https://doi.org/10.1186/s10020-025-01103-x
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