Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients
Background: Polycystic ovarian syndrome (PCOS) and thyroid disorders are the most common endocrine disorders in women. Evidently, the involvement of polycystic ovarian syndrome (PCOS) and thyroid autoimmunity triggering thyroid disorders has not yet occurred. Objective: The aim was to assess serum f...
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Bucharest College of Physicians
2020-10-01
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| author | Rofida Abuobaida KAMIL Nuha Eljailli ABUBAKER Seifeldeen Ahmed MOHAMED Mariam Abbas IBRAHIM Ahmed Bakheet ABD ALLA |
| author_facet | Rofida Abuobaida KAMIL Nuha Eljailli ABUBAKER Seifeldeen Ahmed MOHAMED Mariam Abbas IBRAHIM Ahmed Bakheet ABD ALLA |
| author_sort | Rofida Abuobaida KAMIL |
| collection | DOAJ |
| description | Background: Polycystic ovarian syndrome (PCOS) and thyroid disorders are the most common endocrine disorders in women. Evidently, the involvement of polycystic ovarian syndrome (PCOS) and thyroid autoimmunity triggering thyroid disorders has not yet occurred. Objective: The aim was to assess serum free tri-iodothyronine (FT3), free thyroxin (FT4) and anti-thyroglobulin antibodies among polycystic ovary syndrome Sudanese patients. Materials and methods: Fifty Sudanese patients diagnosed with PCOS and 50 healthy age matched females were recruited in this cross-sectional controlled study. Serum FT3 and FT4 were measured by an immunoassay analyzer and serum anti-thyroglobulin antibodies were measured using ELISA. The data was then analyzed using the SPSS. Results: The results showed a significant increase in serum FT3 and anti-thyroglobulin antibodies and there was no statistical difference in PCOS serum FT4 levels compared to the control group. The results revealed no correlation between levels of FT3, FT4 and anti-thyroglobulin antibodies with age; also there were no correlation between levels of FT3 and FT4 with BMI while there was a positive correlation between anti-thyroglobulin antibodies levels and BMI. Conclusion: Patients with PCOS had elevated FT3 and antithyroglobulin. Therefore, the assessment of thyroid autoantibody with thyroid hormones in patients with PCOS should be investigated. |
| format | Article |
| id | doaj-art-5d3424b7b7e04ca58b5497ca217d65c4 |
| institution | Kabale University |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Bucharest College of Physicians |
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| series | Modern Medicine |
| spelling | doaj-art-5d3424b7b7e04ca58b5497ca217d65c42025-08-20T03:34:42ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732020-10-01273191194https://doi.org/10.31689/rmm.2020.27.3.191Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome PatientsRofida Abuobaida KAMIL0Nuha Eljailli ABUBAKER1Seifeldeen Ahmed MOHAMED2Mariam Abbas IBRAHIM3Ahmed Bakheet ABD ALLA4Department of Clinical Chemistry, Faculty of Medical Laboratories Sciences, Alneelain University, Khartoum, SudanDepartment of Clinical Chemistry, College of Medical Laboratory Science, University of Science and Technology, Khartoum, SudanDepartment of Clinical Chemistry, College of Medical Laboratory Science, University of Science and Technology, Khartoum, SudanDepartment of Clinical Chemistry, College of Medical Laboratory Science, University of Science and Technology, Khartoum, SudanDepartment of Parasitology and Medical Entomology, College of Medical Laboratory Science, University of Science and Technology, Khartoum, SudanBackground: Polycystic ovarian syndrome (PCOS) and thyroid disorders are the most common endocrine disorders in women. Evidently, the involvement of polycystic ovarian syndrome (PCOS) and thyroid autoimmunity triggering thyroid disorders has not yet occurred. Objective: The aim was to assess serum free tri-iodothyronine (FT3), free thyroxin (FT4) and anti-thyroglobulin antibodies among polycystic ovary syndrome Sudanese patients. Materials and methods: Fifty Sudanese patients diagnosed with PCOS and 50 healthy age matched females were recruited in this cross-sectional controlled study. Serum FT3 and FT4 were measured by an immunoassay analyzer and serum anti-thyroglobulin antibodies were measured using ELISA. The data was then analyzed using the SPSS. Results: The results showed a significant increase in serum FT3 and anti-thyroglobulin antibodies and there was no statistical difference in PCOS serum FT4 levels compared to the control group. The results revealed no correlation between levels of FT3, FT4 and anti-thyroglobulin antibodies with age; also there were no correlation between levels of FT3 and FT4 with BMI while there was a positive correlation between anti-thyroglobulin antibodies levels and BMI. Conclusion: Patients with PCOS had elevated FT3 and antithyroglobulin. Therefore, the assessment of thyroid autoantibody with thyroid hormones in patients with PCOS should be investigated.https://medicinamoderna.ro/wp-content/uploads/2020/09/RMM_art-9.pdfpolycystic ovary syndromethyroidthyroid autoantibody |
| spellingShingle | Rofida Abuobaida KAMIL Nuha Eljailli ABUBAKER Seifeldeen Ahmed MOHAMED Mariam Abbas IBRAHIM Ahmed Bakheet ABD ALLA Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients Modern Medicine polycystic ovary syndrome thyroid thyroid autoantibody |
| title | Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients |
| title_full | Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients |
| title_fullStr | Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients |
| title_full_unstemmed | Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients |
| title_short | Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients |
| title_sort | evaluation of thyroid hormones and antithyroglobulin antibodies among sudanese polycystic ovarian syndrome patients |
| topic | polycystic ovary syndrome thyroid thyroid autoantibody |
| url | https://medicinamoderna.ro/wp-content/uploads/2020/09/RMM_art-9.pdf |
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