Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia
<b>Aim:</b> The purpose of the study was to determine the levels of acute phase proteins and clinical changes in calves with lipopolysaccharide induced experimental endotoxemia.<p> <b>Materials and Methods:</b> Eight Holstein breed calves were used in the study. Endotox...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=460 |
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| Summary: | <b>Aim:</b> The purpose of the study was to determine the levels
of acute phase proteins and clinical changes in calves with
lipopolysaccharide induced experimental endotoxemia.<p>
<b>Materials and Methods:</b> Eight Holstein breed calves were
used in the study. Endotoxemia was induced via intravenous
administration of 0.1 μg/kg dose of lipopolysaccharide in
50 mL of physiological 0.9% NaCl over 30 min. The calves
were continuously observed for clinical changes during the
experiment, and serum acute phase protein levels were
measured.<p>
<b>Results:</b> Increase in respiratory frequency, tachycardi,
mucosal hyperemia/cyanosis, recumbency, depression,
hyperthermia/hypothermia, and poor suckle reflexes were
observed in all calves after lipopolysaccharide administration.
After lipopolysaccharide infusion, serum haptoglobin
(500±93.2 μg/mL) and serum amyloid A (185±46.6) concentrations
reached peak levels of at 36 h and 24 h, respectively.<p>
<b>Conclusion:</b> Changes in acute phase proteins and clinical
findings were related to endotoxemia. A moderate to high
increase in haptoglobin and serum amyloid A concentrations
may indicate the presence of endotoxemia in calves. |
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| ISSN: | 1309-6958 2146-1953 |