Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology
The synthesis of natural and unconventional compounds with carbohydrate structures is of great interest to glycochemists due to their vital biological roles. In recent years, there has been significant progress in developing direct and indirect synthetic strategies for constructing sugar moieties. A...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2624-781X/6/1/3 |
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| author | Sateesh Dubbu Santhi Jampani |
| author_facet | Sateesh Dubbu Santhi Jampani |
| author_sort | Sateesh Dubbu |
| collection | DOAJ |
| description | The synthesis of natural and unconventional compounds with carbohydrate structures is of great interest to glycochemists due to their vital biological roles. In recent years, there has been significant progress in developing direct and indirect synthetic strategies for constructing sugar moieties. Among these methods, the Prins reaction, employing homoallylic alcohols and carbonyl compounds, has proven invaluable for directly creating sugar skeletons. This review discusses approaches for crafting carbohydrate frameworks using the Prins reaction, utilizing both carbohydrate and non-carbohydrate starting materials. |
| format | Article |
| id | doaj-art-5d2cf65cc9cf499cb7aece2a7ac47a87 |
| institution | DOAJ |
| issn | 2624-781X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Reactions |
| spelling | doaj-art-5d2cf65cc9cf499cb7aece2a7ac47a872025-08-20T02:43:06ZengMDPI AGReactions2624-781X2025-01-0161310.3390/reactions6010003Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization MethodologySateesh Dubbu0Santhi Jampani1Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, IL 61801, USADepartment of Earth, Ocean & Atmospheric Sciences, The University of British Columbia, Vancouver, BC V6T 1Z1, CanadaThe synthesis of natural and unconventional compounds with carbohydrate structures is of great interest to glycochemists due to their vital biological roles. In recent years, there has been significant progress in developing direct and indirect synthetic strategies for constructing sugar moieties. Among these methods, the Prins reaction, employing homoallylic alcohols and carbonyl compounds, has proven invaluable for directly creating sugar skeletons. This review discusses approaches for crafting carbohydrate frameworks using the Prins reaction, utilizing both carbohydrate and non-carbohydrate starting materials.https://www.mdpi.com/2624-781X/6/1/3carbohydratesPrins reaction2-deoxysuagrshomoallylic alcoholsrare sugars |
| spellingShingle | Sateesh Dubbu Santhi Jampani Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology Reactions carbohydrates Prins reaction 2-deoxysuagrs homoallylic alcohols rare sugars |
| title | Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology |
| title_full | Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology |
| title_fullStr | Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology |
| title_full_unstemmed | Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology |
| title_short | Advancements in Carbohydrate Scaffold Synthesis: Exploring Prins Cyclization Methodology |
| title_sort | advancements in carbohydrate scaffold synthesis exploring prins cyclization methodology |
| topic | carbohydrates Prins reaction 2-deoxysuagrs homoallylic alcohols rare sugars |
| url | https://www.mdpi.com/2624-781X/6/1/3 |
| work_keys_str_mv | AT sateeshdubbu advancementsincarbohydratescaffoldsynthesisexploringprinscyclizationmethodology AT santhijampani advancementsincarbohydratescaffoldsynthesisexploringprinscyclizationmethodology |