How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin
Assisted reproductive technologies (ART) have experienced growing interest from infertile patients seeking to become pregnant. The quality of oocytes plays a pivotal role in determining ART outcomes. Although many authors have studied how supplementation therapy may affect this important parameter f...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/4987436 |
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| author | Salvatore Giovanni Vitale Paola Rossetti Francesco Corrado Agnese Maria Chiara Rapisarda Sandro La Vignera Rosita Angela Condorelli Gaetano Valenti Fabrizio Sapia Antonio Simone Laganà Massimo Buscema |
| author_facet | Salvatore Giovanni Vitale Paola Rossetti Francesco Corrado Agnese Maria Chiara Rapisarda Sandro La Vignera Rosita Angela Condorelli Gaetano Valenti Fabrizio Sapia Antonio Simone Laganà Massimo Buscema |
| author_sort | Salvatore Giovanni Vitale |
| collection | DOAJ |
| description | Assisted reproductive technologies (ART) have experienced growing interest from infertile patients seeking to become pregnant. The quality of oocytes plays a pivotal role in determining ART outcomes. Although many authors have studied how supplementation therapy may affect this important parameter for both in vivo and in vitro models, data are not yet robust enough to support firm conclusions. Regarding this last point, in this review our objective has been to evaluate the state of the art regarding supplementation with melatonin and myo-inositol in order to improve oocyte quality during ART. On the one hand, the antioxidant effect of melatonin is well known as being useful during ovulation and oocyte incubation, two occasions with a high level of oxidative stress. On the other hand, myo-inositol is important in cellular structure and in cellular signaling pathways. Our analysis suggests that the use of these two molecules may significantly improve the quality of oocytes and the quality of embryos: melatonin seems to raise the fertilization rate, and myo-inositol improves the pregnancy rate, although all published studies do not fully agree with these conclusions. However, previous studies have demonstrated that cotreatment improves these results compared with melatonin alone or myo-inositol alone. We recommend that further studies be performed in order to confirm these positive outcomes in routine ART treatment. |
| format | Article |
| id | doaj-art-5d2afae68868467aabd28df41bb60ef2 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5d2afae68868467aabd28df41bb60ef22025-08-20T03:34:42ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/49874364987436How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and MelatoninSalvatore Giovanni Vitale0Paola Rossetti1Francesco Corrado2Agnese Maria Chiara Rapisarda3Sandro La Vignera4Rosita Angela Condorelli5Gaetano Valenti6Fabrizio Sapia7Antonio Simone Laganà8Massimo Buscema9Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, ItalyUnit of Diabetology and Endocrino-Metabolic Diseases, Hospital for Emergency Cannizzaro, Catania, ItalyUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, ItalyDepartment of General Surgery and Medical Surgical Specialties, University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes (CRAMD), University of Catania, Catania, ItalyDepartment of Clinical and Experimental Medicine, Research Centre of Motor Activity and Metabolic Rehabilitation in Diabetes (CRAMD), University of Catania, Catania, ItalyDepartment of General Surgery and Medical Surgical Specialties, University of Catania, Catania, ItalyDepartment of General Surgery and Medical Surgical Specialties, University of Catania, Catania, ItalyUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University of Messina, Messina, ItalyUnit of Diabetology and Endocrino-Metabolic Diseases, Hospital for Emergency Cannizzaro, Catania, ItalyAssisted reproductive technologies (ART) have experienced growing interest from infertile patients seeking to become pregnant. The quality of oocytes plays a pivotal role in determining ART outcomes. Although many authors have studied how supplementation therapy may affect this important parameter for both in vivo and in vitro models, data are not yet robust enough to support firm conclusions. Regarding this last point, in this review our objective has been to evaluate the state of the art regarding supplementation with melatonin and myo-inositol in order to improve oocyte quality during ART. On the one hand, the antioxidant effect of melatonin is well known as being useful during ovulation and oocyte incubation, two occasions with a high level of oxidative stress. On the other hand, myo-inositol is important in cellular structure and in cellular signaling pathways. Our analysis suggests that the use of these two molecules may significantly improve the quality of oocytes and the quality of embryos: melatonin seems to raise the fertilization rate, and myo-inositol improves the pregnancy rate, although all published studies do not fully agree with these conclusions. However, previous studies have demonstrated that cotreatment improves these results compared with melatonin alone or myo-inositol alone. We recommend that further studies be performed in order to confirm these positive outcomes in routine ART treatment.http://dx.doi.org/10.1155/2016/4987436 |
| spellingShingle | Salvatore Giovanni Vitale Paola Rossetti Francesco Corrado Agnese Maria Chiara Rapisarda Sandro La Vignera Rosita Angela Condorelli Gaetano Valenti Fabrizio Sapia Antonio Simone Laganà Massimo Buscema How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin International Journal of Endocrinology |
| title | How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin |
| title_full | How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin |
| title_fullStr | How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin |
| title_full_unstemmed | How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin |
| title_short | How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin |
| title_sort | how to achieve high quality oocytes the key role of myo inositol and melatonin |
| url | http://dx.doi.org/10.1155/2016/4987436 |
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