Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome
Introduction. Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/2316986 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550906278707200 |
|---|---|
| author | Agnieszka Adamska Agnieszka Łebkowska Małgorzata Jacewicz Anna Krentowska Justyna Hryniewicka Sławomir Wołczyński Maria Górska Irina Kowalska |
| author_facet | Agnieszka Adamska Agnieszka Łebkowska Małgorzata Jacewicz Anna Krentowska Justyna Hryniewicka Sławomir Wołczyński Maria Górska Irina Kowalska |
| author_sort | Agnieszka Adamska |
| collection | DOAJ |
| description | Introduction. Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. Methods. The study group comprised 43 women with PCOS and 16 controls. IR was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated with HOMA-B. An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed. Results. Glucose load resulted in an increase in serum betatrophin concentrations in the control group (p=0.02). Serum betatrophin concentrations at 120 min of OGTT were lower in women with PCOS than in the control group (p=0.02). We observed positive correlations between baseline serum betatrophin concentrations and HOMA-IR (r=0.39, p=0.008), negative correlations with Matsuda index (r=−0.31, p=0.004), and a positive relationship with HOMA-B (r=0.38, p=0.01) in women with PCOS. Multiple regression analysis revealed that HOMA-B (β=0.47, p=0.001) was an independent factor connected to serum betatrophin levels in PCOS. Conclusions. Serum concentrations of betatrophin are connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS. |
| format | Article |
| id | doaj-art-5d27f33b69684e3d8c1d4faafbf1ed68 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5d27f33b69684e3d8c1d4faafbf1ed682025-02-03T06:05:23ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/23169862316986Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary SyndromeAgnieszka Adamska0Agnieszka Łebkowska1Małgorzata Jacewicz2Anna Krentowska3Justyna Hryniewicka4Sławomir Wołczyński5Maria Górska6Irina Kowalska7Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, PolandDepartment of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, PolandIntroduction. Data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group. Methods. The study group comprised 43 women with PCOS and 16 controls. IR was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated with HOMA-B. An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed. Results. Glucose load resulted in an increase in serum betatrophin concentrations in the control group (p=0.02). Serum betatrophin concentrations at 120 min of OGTT were lower in women with PCOS than in the control group (p=0.02). We observed positive correlations between baseline serum betatrophin concentrations and HOMA-IR (r=0.39, p=0.008), negative correlations with Matsuda index (r=−0.31, p=0.004), and a positive relationship with HOMA-B (r=0.38, p=0.01) in women with PCOS. Multiple regression analysis revealed that HOMA-B (β=0.47, p=0.001) was an independent factor connected to serum betatrophin levels in PCOS. Conclusions. Serum concentrations of betatrophin are connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS.http://dx.doi.org/10.1155/2017/2316986 |
| spellingShingle | Agnieszka Adamska Agnieszka Łebkowska Małgorzata Jacewicz Anna Krentowska Justyna Hryniewicka Sławomir Wołczyński Maria Górska Irina Kowalska Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome International Journal of Endocrinology |
| title | Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome |
| title_full | Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome |
| title_fullStr | Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome |
| title_short | Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome |
| title_sort | serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome |
| url | http://dx.doi.org/10.1155/2017/2316986 |
| work_keys_str_mv | AT agnieszkaadamska serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome AT agnieszkałebkowska serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome AT małgorzatajacewicz serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome AT annakrentowska serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome AT justynahryniewicka serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome AT sławomirwołczynski serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome AT mariagorska serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome AT irinakowalska serumconcentrationsofbetatrophinanditsassociationwithindirectindicesofinsulinresistanceandbetacellfunctioninwomenwithpolycysticovarysyndrome |