A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation
Abstract Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1–4 mM). This study characterized cardiac function and blood flow responses to a ketogenic beverage compared to a volume/calorie matched placebo with repeated imaging over 120...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70208 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849391904049856512 |
|---|---|
| author | Christopher D. Crabtree Yue Pan Preethi Chandrasekaran Yuwei Wang Debbie Scandling Teryn Bedell Justen Stoner Drew Decker Madison Kackley Bradley Robinson Alex Buga Yuchi Han Jeff Volek Orlando P. Simonetti |
| author_facet | Christopher D. Crabtree Yue Pan Preethi Chandrasekaran Yuwei Wang Debbie Scandling Teryn Bedell Justen Stoner Drew Decker Madison Kackley Bradley Robinson Alex Buga Yuchi Han Jeff Volek Orlando P. Simonetti |
| author_sort | Christopher D. Crabtree |
| collection | DOAJ |
| description | Abstract Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1–4 mM). This study characterized cardiac function and blood flow responses to a ketogenic beverage compared to a volume/calorie matched placebo with repeated imaging over 120 min. This was a two‐group, placebo‐controlled, acute cardiac imaging study. Adults without cardiac abnormalities underwent baseline cardiac MRI including quantitative myocardial perfusion to measure myocardial blood flow (MBF). Subjects consumed 50 g of a ketogenic‐promoting beverage [bis‐hexanoyl R‐1‐3‐butanediol (BH‐BD)] (BH‐BD; n = 11) or a calorically/volume‐matched lipid‐based placebo (PL; n = 10) with cardiac MRI every 15–30 min. Following 120 min, subjects underwent a final scan including MBF measurement. R‐BHB and glucose were measured at every timepoint. 120 min following BH‐BD consumption, R‐BHB reached 2.1 mM. Cardiac output (CO) was elevated compared to PL (p < 0.05) and increased +31% 120 min after BH‐BD ingestion (p < 0.001). CO elevation was due to increased stroke volume (+11%; p = 0.02) and heart rate (+22%; p < 0.001). MBF increased 29% from baseline (p < 0.001). PL did not induce differences in cardiac parameters. 50 g BH‐BD ingestion achieves exogenous ketosis and is associated with elevated MBF and CO providing evidence supporting their use as a therapeutic clinical agent. |
| format | Article |
| id | doaj-art-5d264b43942140eba1aba2c8b70b63ce |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-5d264b43942140eba1aba2c8b70b63ce2025-08-20T03:40:54ZengWileyPhysiological Reports2051-817X2025-03-01136n/an/a10.14814/phy2.70208A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigationChristopher D. Crabtree0Yue Pan1Preethi Chandrasekaran2Yuwei Wang3Debbie Scandling4Teryn Bedell5Justen Stoner6Drew Decker7Madison Kackley8Bradley Robinson9Alex Buga10Yuchi Han11Jeff Volek12Orlando P. Simonetti13Department of Radiology The Ohio State University Columbus Ohio USADepartment of Radiology The Ohio State University Columbus Ohio USADepartment of Biomedical Engineering The Ohio State University Columbus Ohio USADivision of Cardiovascular Medicine, Department of Internal Medicine The Ohio State University Columbus Ohio USADepartment of Radiology The Ohio State University Columbus Ohio USADepartment of Human Sciences The Ohio State University Columbus Ohio USADepartment of Human Sciences The Ohio State University Columbus Ohio USADepartment of Human Sciences The Ohio State University Columbus Ohio USADepartment of Human Sciences The Ohio State University Columbus Ohio USADepartment of Human Sciences The Ohio State University Columbus Ohio USADepartment of Human Sciences The Ohio State University Columbus Ohio USADivision of Cardiovascular Medicine, Department of Internal Medicine The Ohio State University Columbus Ohio USADepartment of Human Sciences The Ohio State University Columbus Ohio USADepartment of Radiology The Ohio State University Columbus Ohio USAAbstract Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1–4 mM). This study characterized cardiac function and blood flow responses to a ketogenic beverage compared to a volume/calorie matched placebo with repeated imaging over 120 min. This was a two‐group, placebo‐controlled, acute cardiac imaging study. Adults without cardiac abnormalities underwent baseline cardiac MRI including quantitative myocardial perfusion to measure myocardial blood flow (MBF). Subjects consumed 50 g of a ketogenic‐promoting beverage [bis‐hexanoyl R‐1‐3‐butanediol (BH‐BD)] (BH‐BD; n = 11) or a calorically/volume‐matched lipid‐based placebo (PL; n = 10) with cardiac MRI every 15–30 min. Following 120 min, subjects underwent a final scan including MBF measurement. R‐BHB and glucose were measured at every timepoint. 120 min following BH‐BD consumption, R‐BHB reached 2.1 mM. Cardiac output (CO) was elevated compared to PL (p < 0.05) and increased +31% 120 min after BH‐BD ingestion (p < 0.001). CO elevation was due to increased stroke volume (+11%; p = 0.02) and heart rate (+22%; p < 0.001). MBF increased 29% from baseline (p < 0.001). PL did not induce differences in cardiac parameters. 50 g BH‐BD ingestion achieves exogenous ketosis and is associated with elevated MBF and CO providing evidence supporting their use as a therapeutic clinical agent.https://doi.org/10.14814/phy2.70208cardiac functioncardiac MRIketonesmetabolic imagingmyocardial perfusion |
| spellingShingle | Christopher D. Crabtree Yue Pan Preethi Chandrasekaran Yuwei Wang Debbie Scandling Teryn Bedell Justen Stoner Drew Decker Madison Kackley Bradley Robinson Alex Buga Yuchi Han Jeff Volek Orlando P. Simonetti A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation Physiological Reports cardiac function cardiac MRI ketones metabolic imaging myocardial perfusion |
| title | A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation |
| title_full | A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation |
| title_fullStr | A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation |
| title_full_unstemmed | A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation |
| title_short | A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation |
| title_sort | ketogenic promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults a cardiac mri investigation |
| topic | cardiac function cardiac MRI ketones metabolic imaging myocardial perfusion |
| url | https://doi.org/10.14814/phy2.70208 |
| work_keys_str_mv | AT christopherdcrabtree aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT yuepan aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT preethichandrasekaran aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT yuweiwang aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT debbiescandling aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT terynbedell aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT justenstoner aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT drewdecker aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT madisonkackley aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT bradleyrobinson aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT alexbuga aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT yuchihan aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT jeffvolek aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT orlandopsimonetti aketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT christopherdcrabtree ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT yuepan ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT preethichandrasekaran ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT yuweiwang ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT debbiescandling ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT terynbedell ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT justenstoner ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT drewdecker ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT madisonkackley ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT bradleyrobinson ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT alexbuga ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT yuchihan ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT jeffvolek ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation AT orlandopsimonetti ketogenicpromotingbeverageacutelyelevatescardiacfunctionandmyocardialbloodflowcomparedtoplaceboinadultsacardiacmriinvestigation |