A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation

A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation

Abstract Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1–4 mM). This study characterized cardiac function and blood flow responses to a ketogenic beverage compared to a volume/calorie matched placebo with repeated imaging over 120...

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Main Authors: Christopher D. Crabtree, Yue Pan, Preethi Chandrasekaran, Yuwei Wang, Debbie Scandling, Teryn Bedell, Justen Stoner, Drew Decker, Madison Kackley, Bradley Robinson, Alex Buga, Yuchi Han, Jeff Volek, Orlando P. Simonetti
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Physiological Reports
Subjects:
cardiac function
cardiac MRI
ketones
metabolic imaging
myocardial perfusion
Online Access:https://doi.org/10.14814/phy2.70208
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Summary:Abstract Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1–4 mM). This study characterized cardiac function and blood flow responses to a ketogenic beverage compared to a volume/calorie matched placebo with repeated imaging over 120 min. This was a two‐group, placebo‐controlled, acute cardiac imaging study. Adults without cardiac abnormalities underwent baseline cardiac MRI including quantitative myocardial perfusion to measure myocardial blood flow (MBF). Subjects consumed 50 g of a ketogenic‐promoting beverage [bis‐hexanoyl R‐1‐3‐butanediol (BH‐BD)] (BH‐BD; n = 11) or a calorically/volume‐matched lipid‐based placebo (PL; n = 10) with cardiac MRI every 15–30 min. Following 120 min, subjects underwent a final scan including MBF measurement. R‐BHB and glucose were measured at every timepoint. 120 min following BH‐BD consumption, R‐BHB reached 2.1 mM. Cardiac output (CO) was elevated compared to PL (p < 0.05) and increased +31% 120 min after BH‐BD ingestion (p < 0.001). CO elevation was due to increased stroke volume (+11%; p = 0.02) and heart rate (+22%; p < 0.001). MBF increased 29% from baseline (p < 0.001). PL did not induce differences in cardiac parameters. 50 g BH‐BD ingestion achieves exogenous ketosis and is associated with elevated MBF and CO providing evidence supporting their use as a therapeutic clinical agent.
ISSN:2051-817X

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