miR-221 activates Sox11 to reduce brain injury after intracerebral hemorrhage via inhibiting neuroinflammation

miR-221 activates Sox11 to reduce brain injury after intracerebral hemorrhage via inhibiting neuroinflammation

Abstract As a global public health issue, intracerebral hemorrhage (ICH) is characterized by high morbidity and mortality. Brain injury following ICH is composed of primary and secondary injury, with the latter being more severe and resulting in increased apoptosis. Sox11 (sex-determining region Y-r...

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Bibliographic Details
Main Authors: Tianyu Liang, Yongchun Liu, Renyang Liu, Xianmei Shen, Mingxia Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Sox11
MiR-221
Secondary brain injury
Intracerebral hemorrhage
Neuroinflammation
Online Access:https://doi.org/10.1038/s41598-025-15239-7
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