The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders
Background: The role of biological aging in the relationship between household air pollution (HAP) from polluting cooking fuels and neuropsychiatric diseases remains unclear. Methods: This nationwide cohort study enrolled 8550 participants aged 45–80 from 2011 to 2020. Biological age based on Klemer...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015252 |
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| author | Rui Tang Haisheng Wu Ling Jiang Jie Zhou Xia Gao Jiazhen Zheng Ya-Ping Tang Mingxi Tang |
| author_facet | Rui Tang Haisheng Wu Ling Jiang Jie Zhou Xia Gao Jiazhen Zheng Ya-Ping Tang Mingxi Tang |
| author_sort | Rui Tang |
| collection | DOAJ |
| description | Background: The role of biological aging in the relationship between household air pollution (HAP) from polluting cooking fuels and neuropsychiatric diseases remains unclear. Methods: This nationwide cohort study enrolled 8550 participants aged 45–80 from 2011 to 2020. Biological age based on Klemera−Doubal method (KDM-BA) was derived from 11 clinical biomarkers. The associations of switching cooking fuels with KDM-BA acceleration (KDM-BAA) and neuropsychiatric diseases were elucidated by generalized linear models and Cox proportional hazard models, respectively. The mediating effects of KDM-BAA on associations between polluting cooking fuel and neuropsychiatric diseases were further examined. We also evaluated the potential of leisure engagement in attenuating KDM-BAA associated with polluting cooking fuels. Results: Compared to consistent use of cleaner fuels, consistent solid fuel use was associated with a 0.12 (95 % CI: 0.05, 0.18) year increase in KDM-BAA, a 25 % higher risk of neurological disease (HR = 1.25, 95 % CI: 1.03, 1.54), and a 34 % increased risk of psychiatric disorders (HR = 1.34, 95 % CI: 1.02, 1.78). Mediation analysis revealed that KDM-BAA significantly mediated the association between solid cooking fuel and neuropsychiatric diseases, with mediated proportions of 5.96 % (P = 0.006) for neurological disease and 5.71 % (P = 0.024) for psychiatric disease. Leisure engagement demonstrated stable benefits in attenuating KDM-BAA independently of cooking fuel use. Conclusion: Our findings illuminate the pathways connecting HAP from solid fuel consumption with biological aging and neuropsychiatric disorders, and highlight the role of leisure engagement and expanding access to cleaner fuels in mitigating these adverse effects. |
| format | Article |
| id | doaj-art-5d232afed065446dac30119b511806ce |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-5d232afed065446dac30119b511806ce2025-01-23T05:25:36ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117449The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disordersRui Tang0Haisheng Wu1Ling Jiang2Jie Zhou3Xia Gao4Jiazhen Zheng5Ya-Ping Tang6Mingxi Tang7Department of Pathology, Yaan People’s Hospital (Yaan Hospital of West China Hospital of Sichuan University), Yaan 625000, China; Department of Pathology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, ChinaSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, 999077, Hong KongWest China Hospital, Sichuan University, Chengdu 610041, ChinaWest China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology, Yaan People’s Hospital (Yaan Hospital of West China Hospital of Sichuan University), Yaan 625000, ChinaBioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511453, ChinaGuangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, China; Department of Cell Biology and Anatomy, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States; Corresponding author at: Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Pathology, Yaan People’s Hospital (Yaan Hospital of West China Hospital of Sichuan University), Yaan 625000, China; Department of Pathology, The Affiliated Hospital, Southwest Medical University, Luzhou 646000, China; Precision Medicine Center, Yaan People’s Hospital (Yaan Hospital of West China Hospital of Sichuan University), Yaan 625000, China; Corresponding author at: Department of Pathology, Yaan People’s Hospital (Yaan Hospital of West China Hospital of Sichuan University), Yaan 625000, ChinaBackground: The role of biological aging in the relationship between household air pollution (HAP) from polluting cooking fuels and neuropsychiatric diseases remains unclear. Methods: This nationwide cohort study enrolled 8550 participants aged 45–80 from 2011 to 2020. Biological age based on Klemera−Doubal method (KDM-BA) was derived from 11 clinical biomarkers. The associations of switching cooking fuels with KDM-BA acceleration (KDM-BAA) and neuropsychiatric diseases were elucidated by generalized linear models and Cox proportional hazard models, respectively. The mediating effects of KDM-BAA on associations between polluting cooking fuel and neuropsychiatric diseases were further examined. We also evaluated the potential of leisure engagement in attenuating KDM-BAA associated with polluting cooking fuels. Results: Compared to consistent use of cleaner fuels, consistent solid fuel use was associated with a 0.12 (95 % CI: 0.05, 0.18) year increase in KDM-BAA, a 25 % higher risk of neurological disease (HR = 1.25, 95 % CI: 1.03, 1.54), and a 34 % increased risk of psychiatric disorders (HR = 1.34, 95 % CI: 1.02, 1.78). Mediation analysis revealed that KDM-BAA significantly mediated the association between solid cooking fuel and neuropsychiatric diseases, with mediated proportions of 5.96 % (P = 0.006) for neurological disease and 5.71 % (P = 0.024) for psychiatric disease. Leisure engagement demonstrated stable benefits in attenuating KDM-BAA independently of cooking fuel use. Conclusion: Our findings illuminate the pathways connecting HAP from solid fuel consumption with biological aging and neuropsychiatric disorders, and highlight the role of leisure engagement and expanding access to cleaner fuels in mitigating these adverse effects.http://www.sciencedirect.com/science/article/pii/S0147651324015252Neuropsychiatric diseaseSolid fuelHousehold air pollutionBiological agingLeisure engagement |
| spellingShingle | Rui Tang Haisheng Wu Ling Jiang Jie Zhou Xia Gao Jiazhen Zheng Ya-Ping Tang Mingxi Tang The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders Ecotoxicology and Environmental Safety Neuropsychiatric disease Solid fuel Household air pollution Biological aging Leisure engagement |
| title | The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders |
| title_full | The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders |
| title_fullStr | The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders |
| title_full_unstemmed | The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders |
| title_short | The mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders |
| title_sort | mediating role of accelerated biological aging in the association between household air pollution from solid cooking fuels and neuropsychiatric disorders |
| topic | Neuropsychiatric disease Solid fuel Household air pollution Biological aging Leisure engagement |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015252 |
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