The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Model

The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Model

Human parainfluenza virus type 3 (HPIV-3) can cause severe respiratory diseases, particularly in young children, the elderly and immunocompromised. There are no approved antiviral drugs against this virus. We report that the combination of ribavirin with either remdesivir or its parent nucleoside GS...

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Bibliographic Details
Main Authors: Yuxia Lin, Birgit Weynand, Xin Zhang, Manon Laporte, Dirk Jochmans, Johan Neyts
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Viruses
Subjects:
parainfluenza viruses
human respirovirus 3
remdesivir
obeldesivir
ribavirin
AG129 mice
Online Access:https://www.mdpi.com/1999-4915/17/2/172
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