Safety and efficacy of simple training protocol in patients after mild traumatic brain injury
Aims. Mild Traumatic Brain Injury (mTBI) is the most common type of craniocerebral injury. Proper management appears to be a key factor in preventing post-concussion syndrome. The aim of this prospective study was to evaluate the effect and safety of selected training protocol in patients after mTBI...
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| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2024-11-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-202404-0004_safety-and-efficacy-of-simple-training-protocol-in-patients-after-mild-traumatic-brain-injury.php |
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| author | Martina Martinikova Robert Ruzinak Petra Hnilicova Michal Bittsansky Marian Grendar Lucia Babalova Pavol Skacik Ema Kantorova Vladimir Nosal Monika Turcanova Koprusakova Jozef Sivak Jana Sivakova Zuzana Biringerova Branislav Kolarovszki Kamil Zelenak Egon Kurca Stefan Sivak |
| author_facet | Martina Martinikova Robert Ruzinak Petra Hnilicova Michal Bittsansky Marian Grendar Lucia Babalova Pavol Skacik Ema Kantorova Vladimir Nosal Monika Turcanova Koprusakova Jozef Sivak Jana Sivakova Zuzana Biringerova Branislav Kolarovszki Kamil Zelenak Egon Kurca Stefan Sivak |
| author_sort | Martina Martinikova |
| collection | DOAJ |
| description | Aims. Mild Traumatic Brain Injury (mTBI) is the most common type of craniocerebral injury. Proper management appears to be a key factor in preventing post-concussion syndrome. The aim of this prospective study was to evaluate the effect and safety of selected training protocol in patients after mTBI. Methods. This was a prospective study that included 25 patients with mTBI and 25 matched healthy controls. Assessments were performed in two sessions and included a post-concussion symptoms questionnaire, battery of neurocognitive tests, and magnetic resonance with tractography. Participants were divided into two groups: a passive subgroup with no specific recommendations and an active subgroup with simple physical and cognitive training. Results. The training program with slightly higher initial physical and cognitive loads was well tolerated and was harmless according to the noninferiority test. The tractography showed overall temporal posttraumatic changes in the brain. The predictive model was able to distinguish between patients and controls in the first (AUC=0.807) and second (AUC=0.652) sessions. In general, tractography had an overall predictive dominance of measures. Conclusion. The results from our study objectively point to the safety of our chosen training protocol, simultaneously with the signs of slight benefits in specific cognitive domains. The study also showed the capability of machine learning and predictive models in mTBI patient recognition. |
| format | Article |
| id | doaj-art-5d12a2b2f23d409093df4b374c0dee10 |
| institution | DOAJ |
| issn | 1213-8118 1804-7521 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj-art-5d12a2b2f23d409093df4b374c0dee102025-08-20T02:48:12ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212024-11-01168429530310.5507/bp.2023.013bio-202404-0004Safety and efficacy of simple training protocol in patients after mild traumatic brain injuryMartina Martinikova0Robert Ruzinak1Petra Hnilicova2Michal Bittsansky3Marian Grendar4Lucia Babalova5Pavol Skacik6Ema Kantorova7Vladimir Nosal8Monika Turcanova Koprusakova9Jozef Sivak10Jana Sivakova11Zuzana Biringerova12Branislav Kolarovszki13Kamil ZelenakEgon Kurca14Stefan Sivak15Second Department of Neurology, F. D. Roosevelt Faculty Hospital, Slovak Medical University, Banska Bystrica, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicBiomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicDepartment of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicBiomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicDepartment of Radiology, The Central Slovak Institute for Cardiovascular Diseases in Banska Bystrica, Banska Bystrica, Slovak RepublicClinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicMedical Education Support Center, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurosurgery, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak RepublicAims. Mild Traumatic Brain Injury (mTBI) is the most common type of craniocerebral injury. Proper management appears to be a key factor in preventing post-concussion syndrome. The aim of this prospective study was to evaluate the effect and safety of selected training protocol in patients after mTBI. Methods. This was a prospective study that included 25 patients with mTBI and 25 matched healthy controls. Assessments were performed in two sessions and included a post-concussion symptoms questionnaire, battery of neurocognitive tests, and magnetic resonance with tractography. Participants were divided into two groups: a passive subgroup with no specific recommendations and an active subgroup with simple physical and cognitive training. Results. The training program with slightly higher initial physical and cognitive loads was well tolerated and was harmless according to the noninferiority test. The tractography showed overall temporal posttraumatic changes in the brain. The predictive model was able to distinguish between patients and controls in the first (AUC=0.807) and second (AUC=0.652) sessions. In general, tractography had an overall predictive dominance of measures. Conclusion. The results from our study objectively point to the safety of our chosen training protocol, simultaneously with the signs of slight benefits in specific cognitive domains. The study also showed the capability of machine learning and predictive models in mTBI patient recognition.https://biomed.papers.upol.cz/artkey/bio-202404-0004_safety-and-efficacy-of-simple-training-protocol-in-patients-after-mild-traumatic-brain-injury.phpmild traumatic brain injurytrainingtractographypredictive modelmachine learning |
| spellingShingle | Martina Martinikova Robert Ruzinak Petra Hnilicova Michal Bittsansky Marian Grendar Lucia Babalova Pavol Skacik Ema Kantorova Vladimir Nosal Monika Turcanova Koprusakova Jozef Sivak Jana Sivakova Zuzana Biringerova Branislav Kolarovszki Kamil Zelenak Egon Kurca Stefan Sivak Safety and efficacy of simple training protocol in patients after mild traumatic brain injury Biomedical Papers mild traumatic brain injury training tractography predictive model machine learning |
| title | Safety and efficacy of simple training protocol in patients after mild traumatic brain injury |
| title_full | Safety and efficacy of simple training protocol in patients after mild traumatic brain injury |
| title_fullStr | Safety and efficacy of simple training protocol in patients after mild traumatic brain injury |
| title_full_unstemmed | Safety and efficacy of simple training protocol in patients after mild traumatic brain injury |
| title_short | Safety and efficacy of simple training protocol in patients after mild traumatic brain injury |
| title_sort | safety and efficacy of simple training protocol in patients after mild traumatic brain injury |
| topic | mild traumatic brain injury training tractography predictive model machine learning |
| url | https://biomed.papers.upol.cz/artkey/bio-202404-0004_safety-and-efficacy-of-simple-training-protocol-in-patients-after-mild-traumatic-brain-injury.php |
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