CXCL4 deficiency limits M4 macrophage infiltration and attenuates hyperoxia-induced lung injury

CXCL4 deficiency limits M4 macrophage infiltration and attenuates hyperoxia-induced lung injury

Abstract Background Bronchopulmonary dysplasia (BPD), a chronic lung disease prevalent among premature infants, significantly impacts lifelong respiratory health. Macrophages, as key components of the innate immune system, play a role in lung tissue inflammation and injury, exhibiting diverse and dy...

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Bibliographic Details
Main Authors: Bingrui Yu, Siyuan Jia, Yu Chen, Rong Guan, Shuyu Chen, Wanwen Tang, Tianping Bao, Zhaofang Tian
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
BPD
CXCL4
M4 macrophages
Hyperoxia
Lung injury
Neonatal mice
Online Access:https://doi.org/10.1186/s10020-024-01043-y
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