Circadian Metabolism: What's new in circadian regulation of metabolism
Metabolic diseases, including obesity and diabetes, etc., are a spectrum of life-threatening diseases, in which metabolic dysfunction is a hallmark. It is in urgent need of new insights for the prevention and treatment of the diseases. Circadian rhythm is fundamental in health and wellbeing. Researc...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Army Medical University
2025-02-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | https://aammt.tmmu.edu.cn/html/202501018.html |
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| author | LI Mindian ZHANG Jianxin ZHANG Jianxin |
| author_facet | LI Mindian ZHANG Jianxin ZHANG Jianxin |
| author_sort | LI Mindian |
| collection | DOAJ |
| description | Metabolic diseases, including obesity and diabetes, etc., are a spectrum of life-threatening diseases, in which metabolic dysfunction is a hallmark. It is in urgent need of new insights for the prevention and treatment of the diseases. Circadian rhythm is fundamental in health and wellbeing. Research on circadian rhythm has shed light on metabolic homeostasis, thereby giving birth to a new direction, named circadian metabolism. Here, we summarize recent advances in circadian metabolism regarding organelle regulation, inter- and intra-organ crosstalk of circadian clocks, as well as molecular mechanisms of time-restricted eating, and propose circadian communication across the hierarchy of central and peripheral clocks as a key concept for understanding the temporal regulation of metabolism. The underlying mechanisms on circadian communication should shed light on precision medicine in a temporal resolution and provide guidelines on when to eat and when to exercise for the prevention of metabolic diseases.
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| format | Article |
| id | doaj-art-5d0907bd61c4434ab7b8d2708fa5b329 |
| institution | DOAJ |
| issn | 2097-0927 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj-art-5d0907bd61c4434ab7b8d2708fa5b3292025-08-20T02:45:31ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272025-02-0147428528910.16016/j.2097-0927.202501018Circadian Metabolism: What's new in circadian regulation of metabolismLI Mindian0ZHANG Jianxin1ZHANG Jianxin2Department of Cardiovascular Diseases， Center for Circadian Metabolism and Cardiovascular Disease， Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Diseases of Ministry of Education， Southwest Hospital， Army Medical University （Third Military Medical University）， Chongqing Department of Cardiovascular Diseases， Center for Circadian Metabolism and Cardiovascular Disease， Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Diseases of Ministry of Education， Southwest Hospital， Army Medical University （Third Military Medical University）， ChongqingDepartment of Cardiovascular Diseases， The 960th Hospital of the PLA Joint Service Support Force， Jinan， Shandong， ChinaMetabolic diseases, including obesity and diabetes, etc., are a spectrum of life-threatening diseases, in which metabolic dysfunction is a hallmark. It is in urgent need of new insights for the prevention and treatment of the diseases. Circadian rhythm is fundamental in health and wellbeing. Research on circadian rhythm has shed light on metabolic homeostasis, thereby giving birth to a new direction, named circadian metabolism. Here, we summarize recent advances in circadian metabolism regarding organelle regulation, inter- and intra-organ crosstalk of circadian clocks, as well as molecular mechanisms of time-restricted eating, and propose circadian communication across the hierarchy of central and peripheral clocks as a key concept for understanding the temporal regulation of metabolism. The underlying mechanisms on circadian communication should shed light on precision medicine in a temporal resolution and provide guidelines on when to eat and when to exercise for the prevention of metabolic diseases. https://aammt.tmmu.edu.cn/html/202501018.htmlcircadian rhythmcircadian clockmetabolismmetabolic diseases |
| spellingShingle | LI Mindian ZHANG Jianxin ZHANG Jianxin Circadian Metabolism: What's new in circadian regulation of metabolism 陆军军医大学学报 circadian rhythm circadian clock metabolism metabolic diseases |
| title | Circadian Metabolism: What's new in circadian regulation of metabolism |
| title_full | Circadian Metabolism: What's new in circadian regulation of metabolism |
| title_fullStr | Circadian Metabolism: What's new in circadian regulation of metabolism |
| title_full_unstemmed | Circadian Metabolism: What's new in circadian regulation of metabolism |
| title_short | Circadian Metabolism: What's new in circadian regulation of metabolism |
| title_sort | circadian metabolism what s new in circadian regulation of metabolism |
| topic | circadian rhythm circadian clock metabolism metabolic diseases |
| url | https://aammt.tmmu.edu.cn/html/202501018.html |
| work_keys_str_mv | AT limindian circadianmetabolismwhatsnewincircadianregulationofmetabolism AT zhangjianxin circadianmetabolismwhatsnewincircadianregulationofmetabolism AT zhangjianxin circadianmetabolismwhatsnewincircadianregulationofmetabolism |