Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa
Aim: The pathogenetic mechanisms and predictors of the development of polyposis and hypertrophy of the sinonasal mucosa (SM) in patients with chronic allergic airway inflammation have not been clearly established. The concentration of inflammatory biomarkers in nasal secretions was determined in chi...
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Open Exploration Publishing Inc.
2025-04-01
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| Series: | Exploration of Medicine |
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| author | Svetlana Viktorovna Krasilnikova Ekaterina Ivanovna Krestova Tatyana Ivanovna Eliseeva Regina Niyazovna Khramova Ksenia Viktorovna Gorbunova Elena Alekseevna Leontieva Dmitry Yuryevich Ovsyannikov Natalia Anatolievna Geppe Nailya Iskhakovna Kubysheva |
| author_facet | Svetlana Viktorovna Krasilnikova Ekaterina Ivanovna Krestova Tatyana Ivanovna Eliseeva Regina Niyazovna Khramova Ksenia Viktorovna Gorbunova Elena Alekseevna Leontieva Dmitry Yuryevich Ovsyannikov Natalia Anatolievna Geppe Nailya Iskhakovna Kubysheva |
| author_sort | Svetlana Viktorovna Krasilnikova |
| collection | DOAJ |
| description | Aim: The pathogenetic mechanisms and predictors of the development of polyposis and hypertrophy of the sinonasal mucosa (SM) in patients with chronic allergic airway inflammation have not been clearly established. The concentration of inflammatory biomarkers in nasal secretions was determined in children and adolescents with a combined course of bronchial asthma (BA) and allergic rhinitis (AR) in the absence or presence of polyposis and hypertrophy of the SM. Methods: A single-centre observational cross-sectional pilot study was conducted. 93 patients with BA aged 8 to 17 years were studied. Total Nasal Symptom Score (TNSS), sinonasal symptoms (SNOT-22), and peak nasal inspiratory flow (PNIF) were assessed. Concentrations of eosinophil cationic protein (ECP), interleukin 4 (IL-4), IL-1, total immunoglobulin E (IgE), and vascular endothelial growth factor (VEGF) in nasal secretions were determined. Results: The levels of ECP, IL-4, and IL-1 in nasal secretions were statistically significantly higher in patients with the presence of polyposis and hypertrophic SM than in those without, amounting to 83.1 [31.4; 166.8] ng/mL for ECP vs. 29.5 [5.3; 49.9] ng/mL, P < 0.001, for IL-4 174.6 [68.6; 325.5] pg/mL vs. 79.5 [42.8; 146.01] pg/mL, P = 0.004, for IL-1 98.7 [33.7; 267.5] pg/mL and 48.8 [9.01; 108.2] pg/mL, P = 0.025. There were no statistically significant differences in IgE and VEGF levels in nasal secretions, all P > 0.05. Parameters such as ECP, IL-4, and IL-1 were found to be significant predictors of polyposis and hypertrophy in the formation of SM. Conclusions: In patients with a combined course of BA and AR, the presence of polyposis and hypertrophy of SM is associated with higher levels of ECP, IL-4, and IL-1 in nasal secretion. This may indicate that pathological remodelling of SM is associated with both the intensity of allergic inflammation and its relationship with local activation of innate immunity. |
| format | Article |
| id | doaj-art-5d08e6974ec74b96a6f4fca5bec2cf0c |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Open Exploration Publishing Inc. |
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| spelling | doaj-art-5d08e6974ec74b96a6f4fca5bec2cf0c2025-08-20T02:17:40ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062025-04-016100130610.37349/emed.2025.1001306Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosaSvetlana Viktorovna Krasilnikova0https://orcid.org/0000-0001-6153-6691Ekaterina Ivanovna Krestova1https://orcid.org/0009-0008-9948-5242Tatyana Ivanovna Eliseeva2https://orcid.org/0000-0002-1769-3670Regina Niyazovna Khramova3https://orcid.org/0000-0002-2396-5054Ksenia Viktorovna Gorbunova4https://orcid.org/0000-0003-4985-1546Elena Alekseevna Leontieva5https://orcid.org/0009-0000-7293-6471Dmitry Yuryevich Ovsyannikov6https://orcid.org/0000-0002-4961-384XNatalia Anatolievna Geppe7https://orcid.org/0000-0003-0547-3686Nailya Iskhakovna Kubysheva8https://orcid.org/0000-0002-5582-5814Department of Hospital Pediatrics, Federal State Budgetary Educational Institution of Higher Medical Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russian FederationDepartment of Hospital Pediatrics, Federal State Budgetary Educational Institution of Higher Medical Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russian FederationDepartment of Hospital Pediatrics, Federal State Budgetary Educational Institution of Higher Medical Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russian FederationDepartment of Hospital Pediatrics, Federal State Budgetary Educational Institution of Higher Medical Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russian Federation; Institute of Clinical Medicine, Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Russian FederationDepartment of Hospital Pediatrics, Federal State Budgetary Educational Institution of Higher Medical Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russian FederationDepartment of Hospital Pediatrics, Federal State Budgetary Educational Institution of Higher Medical Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, 603950 Nizhny Novgorod, Russian FederationMedical Institute, Peoples’ Friendship University of Russia (RUDN), 117198 Moscow, Russian FederationClinical Institute of Children’s Health named after N.F. Filatov, First Moscow State Medical University named after I.M. Sechenov. (Sechenov University), 119991 Moscow, Russian FederationNeurocognitive Research Laboratory, Kazan Federal University, 420000 Kazan, Russian FederationAim: The pathogenetic mechanisms and predictors of the development of polyposis and hypertrophy of the sinonasal mucosa (SM) in patients with chronic allergic airway inflammation have not been clearly established. The concentration of inflammatory biomarkers in nasal secretions was determined in children and adolescents with a combined course of bronchial asthma (BA) and allergic rhinitis (AR) in the absence or presence of polyposis and hypertrophy of the SM. Methods: A single-centre observational cross-sectional pilot study was conducted. 93 patients with BA aged 8 to 17 years were studied. Total Nasal Symptom Score (TNSS), sinonasal symptoms (SNOT-22), and peak nasal inspiratory flow (PNIF) were assessed. Concentrations of eosinophil cationic protein (ECP), interleukin 4 (IL-4), IL-1, total immunoglobulin E (IgE), and vascular endothelial growth factor (VEGF) in nasal secretions were determined. Results: The levels of ECP, IL-4, and IL-1 in nasal secretions were statistically significantly higher in patients with the presence of polyposis and hypertrophic SM than in those without, amounting to 83.1 [31.4; 166.8] ng/mL for ECP vs. 29.5 [5.3; 49.9] ng/mL, P < 0.001, for IL-4 174.6 [68.6; 325.5] pg/mL vs. 79.5 [42.8; 146.01] pg/mL, P = 0.004, for IL-1 98.7 [33.7; 267.5] pg/mL and 48.8 [9.01; 108.2] pg/mL, P = 0.025. There were no statistically significant differences in IgE and VEGF levels in nasal secretions, all P > 0.05. Parameters such as ECP, IL-4, and IL-1 were found to be significant predictors of polyposis and hypertrophy in the formation of SM. Conclusions: In patients with a combined course of BA and AR, the presence of polyposis and hypertrophy of SM is associated with higher levels of ECP, IL-4, and IL-1 in nasal secretion. This may indicate that pathological remodelling of SM is associated with both the intensity of allergic inflammation and its relationship with local activation of innate immunity.https://www.explorationpub.com/uploads/Article/A1001306/1001306.pdfbronchial asthmaallergic rhinitischildrenadolescentspolypsbiomarkers |
| spellingShingle | Svetlana Viktorovna Krasilnikova Ekaterina Ivanovna Krestova Tatyana Ivanovna Eliseeva Regina Niyazovna Khramova Ksenia Viktorovna Gorbunova Elena Alekseevna Leontieva Dmitry Yuryevich Ovsyannikov Natalia Anatolievna Geppe Nailya Iskhakovna Kubysheva Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa Exploration of Medicine bronchial asthma allergic rhinitis children adolescents polyps biomarkers |
| title | Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa |
| title_full | Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa |
| title_fullStr | Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa |
| title_full_unstemmed | Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa |
| title_short | Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa |
| title_sort | inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa |
| topic | bronchial asthma allergic rhinitis children adolescents polyps biomarkers |
| url | https://www.explorationpub.com/uploads/Article/A1001306/1001306.pdf |
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