Significance of microvessel density in prostate cancer core biopsy
Background/Aim. In prostate tumors, angiogenesis, measured as microvessel density, is associated with tumor stage and Gleason score. The aim of this study was determine neovascularization of prostatic adenocarcinomas in core biopsies and corresponding prostatectomies. Methods. The study pop...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500004S.pdf |
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| author | Salapura-Dugonjić Aleksandra Knežević-Ušaj Slavica Eri Živka Tadić-Latinović Ljiljana |
| author_facet | Salapura-Dugonjić Aleksandra Knežević-Ušaj Slavica Eri Živka Tadić-Latinović Ljiljana |
| author_sort | Salapura-Dugonjić Aleksandra |
| collection | DOAJ |
| description | Background/Aim. In prostate tumors, angiogenesis, measured as microvessel
density, is associated with tumor stage and Gleason score. The aim of this
study was determine neovascularization of prostatic adenocarcinomas in core
biopsies and corresponding prostatectomies. Methods. The study population
included 61 patients who underwent radical prostatectomy (RP) for localized
prostate carcinoma patients and did not receive chemohormonal, or radiation
therapy before surgery. Tumor blocks were immunostained using the
endothelial-specific antibody CD31 and subsequently evaluated at x 400
magnification in both biopsies and corresponding prostatectomies. Results.
When comparing microvessel density in core biopsies and corresponding
prostatectomies, no statistically significant difference was found (p > 0.1).
A statistically significant positive correlation was found when determining
correlation between microvessel density (as linear and categorical variable,
i.e. with the cut-off value of 48) that was associated with the Gleason score
(p < 0.05) and tumor stage (p < 0.0001). There was no correlation between
microvessel density and preoperative values of serum prostate-specific
antigen (PSA) (p > 0.1). Conclusion. Microvessel density can be reliably
applied to needle prostate biopsy specimens. Quantification of the
microvascular density in biopsies is an accurate pre-operative predictor of
tumor stage, discriminating between organconfined and organ-extending
neoplasms. |
| format | Article |
| id | doaj-art-5d041d993aaf4005b7da223671353ed6 |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-5d041d993aaf4005b7da223671353ed62025-08-20T03:18:12ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502015-01-0172431732710.2298/VSP131111004S0042-84501500004SSignificance of microvessel density in prostate cancer core biopsySalapura-Dugonjić Aleksandra0Knežević-Ušaj Slavica1Eri Živka2Tadić-Latinović Ljiljana3Clinical Center of Banja Luka, Institute for Pathology, Republic of Srpska, Bosnia and HerzegovinaInstitute for Oncology, Institute for Pathology, Institute for Pulmonary Diseases, Sremska KamenicaInstitute for Oncology, Institute for Pathology, Sremska KamenicaClinical Center of Banja Luka, Institute for Pathology, Republic of Srpska, Bosnia and HerzegovinaBackground/Aim. In prostate tumors, angiogenesis, measured as microvessel density, is associated with tumor stage and Gleason score. The aim of this study was determine neovascularization of prostatic adenocarcinomas in core biopsies and corresponding prostatectomies. Methods. The study population included 61 patients who underwent radical prostatectomy (RP) for localized prostate carcinoma patients and did not receive chemohormonal, or radiation therapy before surgery. Tumor blocks were immunostained using the endothelial-specific antibody CD31 and subsequently evaluated at x 400 magnification in both biopsies and corresponding prostatectomies. Results. When comparing microvessel density in core biopsies and corresponding prostatectomies, no statistically significant difference was found (p > 0.1). A statistically significant positive correlation was found when determining correlation between microvessel density (as linear and categorical variable, i.e. with the cut-off value of 48) that was associated with the Gleason score (p < 0.05) and tumor stage (p < 0.0001). There was no correlation between microvessel density and preoperative values of serum prostate-specific antigen (PSA) (p > 0.1). Conclusion. Microvessel density can be reliably applied to needle prostate biopsy specimens. Quantification of the microvascular density in biopsies is an accurate pre-operative predictor of tumor stage, discriminating between organconfined and organ-extending neoplasms.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500004S.pdfprostatic neoplasmsbiopsyfine-needleprostatectomyimmunohistochemistryneovascularization, pathologic |
| spellingShingle | Salapura-Dugonjić Aleksandra Knežević-Ušaj Slavica Eri Živka Tadić-Latinović Ljiljana Significance of microvessel density in prostate cancer core biopsy Vojnosanitetski Pregled prostatic neoplasms biopsy fine-needle prostatectomy immunohistochemistry neovascularization, pathologic |
| title | Significance of microvessel density in prostate cancer core biopsy |
| title_full | Significance of microvessel density in prostate cancer core biopsy |
| title_fullStr | Significance of microvessel density in prostate cancer core biopsy |
| title_full_unstemmed | Significance of microvessel density in prostate cancer core biopsy |
| title_short | Significance of microvessel density in prostate cancer core biopsy |
| title_sort | significance of microvessel density in prostate cancer core biopsy |
| topic | prostatic neoplasms biopsy fine-needle prostatectomy immunohistochemistry neovascularization, pathologic |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500004S.pdf |
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