Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait?
Neurilemmomas are benign neoplasms presumedly derived from Schwann cells which rarely originate within the central nervous system. Moreover, their intraventricular location has been seldom noticed with less than 30 cases reported worldwide. Here, we add another case study to the record as well as th...
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/2494175 |
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| author | Miguel Fdo. Salazar Martha Lilia Tena Suck Daniel Rembao Bojórquez Citlaltepetl Salinas Lara |
| author_facet | Miguel Fdo. Salazar Martha Lilia Tena Suck Daniel Rembao Bojórquez Citlaltepetl Salinas Lara |
| author_sort | Miguel Fdo. Salazar |
| collection | DOAJ |
| description | Neurilemmomas are benign neoplasms presumedly derived from Schwann cells which rarely originate within the central nervous system. Moreover, their intraventricular location has been seldom noticed with less than 30 cases reported worldwide. Here, we add another case study to the record as well as the fifth one in Latin American population. A 16-year-old boy without significant past clinical data debuted with headache and progressive left eye blindness during six months. Neuroimaging scans showed a bulky, multiloculated, intraventricular tumour emerging from the posterior horn of the left lateral ventricle. Microscopically, the lesion put on view the classical schwannian histology: spindle cells arranged in both compact and loosely textured areas. Verocay bodies were not present but vessel hyalinisation, pericellular reticulin, and senescent atypia were observed. The immunoperoxidase reactions were also consistent with neurilemmal differentiation; however, glial fibrillary acidic protein expression was widespread and unexpectedly seen. Traditionally conceived as “nerve sheath tumours” the dual immunophenotype herein demonstrated points to a different histogenetical pathway other than sheer Schwann cell derivation. As previously advised by some authors, neoplastic transformation from a multipotent stem cell may explain the occasional finding of these tumours in unconventional intracranial compartments. |
| format | Article |
| id | doaj-art-5d030e77add540adade4f9165caeaa93 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-5d030e77add540adade4f9165caeaa932025-02-03T05:57:41ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/24941752494175Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait?Miguel Fdo. Salazar0Martha Lilia Tena Suck1Daniel Rembao Bojórquez2Citlaltepetl Salinas Lara3Pathology Unit, Neuropathology Service, Mexico General Hospital, Cuauhtémoc, 06726 Mexico City, DF, MexicoDepartment of Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, 14269 Mexico City, DF, MexicoDepartment of Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, 14269 Mexico City, DF, MexicoDepartment of Neuropathology, National Institute of Neurology & Neurosurgery “Manuel Velasco Suárez”, Tlalpan, 14269 Mexico City, DF, MexicoNeurilemmomas are benign neoplasms presumedly derived from Schwann cells which rarely originate within the central nervous system. Moreover, their intraventricular location has been seldom noticed with less than 30 cases reported worldwide. Here, we add another case study to the record as well as the fifth one in Latin American population. A 16-year-old boy without significant past clinical data debuted with headache and progressive left eye blindness during six months. Neuroimaging scans showed a bulky, multiloculated, intraventricular tumour emerging from the posterior horn of the left lateral ventricle. Microscopically, the lesion put on view the classical schwannian histology: spindle cells arranged in both compact and loosely textured areas. Verocay bodies were not present but vessel hyalinisation, pericellular reticulin, and senescent atypia were observed. The immunoperoxidase reactions were also consistent with neurilemmal differentiation; however, glial fibrillary acidic protein expression was widespread and unexpectedly seen. Traditionally conceived as “nerve sheath tumours” the dual immunophenotype herein demonstrated points to a different histogenetical pathway other than sheer Schwann cell derivation. As previously advised by some authors, neoplastic transformation from a multipotent stem cell may explain the occasional finding of these tumours in unconventional intracranial compartments.http://dx.doi.org/10.1155/2016/2494175 |
| spellingShingle | Miguel Fdo. Salazar Martha Lilia Tena Suck Daniel Rembao Bojórquez Citlaltepetl Salinas Lara Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? Case Reports in Pathology |
| title | Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? |
| title_full | Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? |
| title_fullStr | Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? |
| title_full_unstemmed | Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? |
| title_short | Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? |
| title_sort | intraventricular neurilemmoma schwannoma shall gfap immunostaining be regarded as a histogenetical tag or as a mere histomimetical trait |
| url | http://dx.doi.org/10.1155/2016/2494175 |
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