PTTG1 promotes M2 macrophage polarization via the cGMP-PKG signaling pathway and facilitates EMT progression in human epithelial ovarian cancer cells

PTTG1 promotes M2 macrophage polarization via the cGMP-PKG signaling pathway and facilitates EMT progression in human epithelial ovarian cancer cells

Abstract Epithelial Ovarian Cancer (EOC) is complex and heterogeneous, making accurate prognosis and treatment prediction difficult. New therapeutic targets and their mechanisms are urgently needed. This study explored the role of PTTG1 in ovarian cancer via the cGMP-PKG signaling pathway, focusing...

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Bibliographic Details
Main Authors: Liang Tian, Liyun Liu, Chunlou Wang, Yan Kong, Zhigang Miao, Qing Yao, He Zhang, Yuehong Li
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Ovarian cancer
PTTG1
CGMP-PKG signaling pathway
Macrophage polarization
Epithelial-mesenchymal transition
Online Access:https://doi.org/10.1007/s12672-025-02512-4
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