Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications
Cyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in the pharmaceutical field, among which the formation of inclusion complexes (ICs) with natural or synthetic lipophilic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/4/506 |
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| author | Oana Elena Nicolaescu Cătălina Ionescu Adriana Samide Cristian Tigae Cezar Ionuţ Spînu Bogdan Oprea |
| author_facet | Oana Elena Nicolaescu Cătălina Ionescu Adriana Samide Cristian Tigae Cezar Ionuţ Spînu Bogdan Oprea |
| author_sort | Oana Elena Nicolaescu |
| collection | DOAJ |
| description | Cyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in the pharmaceutical field, among which the formation of inclusion complexes (ICs) with natural or synthetic lipophilic compounds. This review prioritizes the research of recent years (2022–2025), being focused on (1) systematization of the research of ICs based on the structure of the secondary metabolite, namely (i) polyphenols (PPs), (ii) terpenes and terpenoids (TTs), and (iii) alkaloids (Alks); (2) for each type of inclusion complex, the following aspects have been discussed: benefits of complexation, composite materials, and in vitro/in vivo and theoretical studies; and (3) pharmacokinetics and pharmacodynamics, risks, limitations, and perspectives of cyclodextrin inclusion complexes with secondary metabolites. |
| format | Article |
| id | doaj-art-5cffcc466fea45b997b8e41e7b020880 |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-5cffcc466fea45b997b8e41e7b0208802025-08-20T02:28:20ZengMDPI AGPharmaceutics1999-49232025-04-0117450610.3390/pharmaceutics17040506Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical ApplicationsOana Elena Nicolaescu0Cătălina Ionescu1Adriana Samide2Cristian Tigae3Cezar Ionuţ Spînu4Bogdan Oprea5Department of Pharmaceutical Technique, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş, 200349 Craiova, Dolj, RomaniaDepartment of Chemistry, Faculty of Sciences, University of Craiova, 107i Calea București, 200144 Craiova, Dolj, RomaniaDepartment of Chemistry, Faculty of Sciences, University of Craiova, 107i Calea București, 200144 Craiova, Dolj, RomaniaDepartment of Chemistry, Faculty of Sciences, University of Craiova, 107i Calea București, 200144 Craiova, Dolj, RomaniaDepartment of Chemistry, Faculty of Sciences, University of Craiova, 107i Calea București, 200144 Craiova, Dolj, RomaniaFaculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares, 200349 Craiova, Dolj, RomaniaCyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in the pharmaceutical field, among which the formation of inclusion complexes (ICs) with natural or synthetic lipophilic compounds. This review prioritizes the research of recent years (2022–2025), being focused on (1) systematization of the research of ICs based on the structure of the secondary metabolite, namely (i) polyphenols (PPs), (ii) terpenes and terpenoids (TTs), and (iii) alkaloids (Alks); (2) for each type of inclusion complex, the following aspects have been discussed: benefits of complexation, composite materials, and in vitro/in vivo and theoretical studies; and (3) pharmacokinetics and pharmacodynamics, risks, limitations, and perspectives of cyclodextrin inclusion complexes with secondary metabolites.https://www.mdpi.com/1999-4923/17/4/506cyclodextrinsnatural compoundssecondary metabolitespolyphenolsterpenes and terpenoidsalkaloids |
| spellingShingle | Oana Elena Nicolaescu Cătălina Ionescu Adriana Samide Cristian Tigae Cezar Ionuţ Spînu Bogdan Oprea Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications Pharmaceutics cyclodextrins natural compounds secondary metabolites polyphenols terpenes and terpenoids alkaloids |
| title | Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications |
| title_full | Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications |
| title_fullStr | Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications |
| title_full_unstemmed | Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications |
| title_short | Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications |
| title_sort | advancements in cyclodextrin complexes with bioactive secondary metabolites and their pharmaceutical applications |
| topic | cyclodextrins natural compounds secondary metabolites polyphenols terpenes and terpenoids alkaloids |
| url | https://www.mdpi.com/1999-4923/17/4/506 |
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