Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers
Benzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual and combined effects on genetic damage at low exposure levels are not fully understood. Additionally, single nucleotide polymorphisms in microRNAs (mirSNPs) might be involved in cancer etiology by affecting the r...
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2024-11-01
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| author | Shuangqi Li Xiaojing Liao Rui Ma Na Deng Haimei Wu Zhaorui Zhang Liping Chen Qing Wang Qilong Liao Qianxi Li Xinyi Ouyang Yongmei Xiao Qifei Deng |
| author_facet | Shuangqi Li Xiaojing Liao Rui Ma Na Deng Haimei Wu Zhaorui Zhang Liping Chen Qing Wang Qilong Liao Qianxi Li Xinyi Ouyang Yongmei Xiao Qifei Deng |
| author_sort | Shuangqi Li |
| collection | DOAJ |
| description | Benzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual and combined effects on genetic damage at low exposure levels are not fully understood. Additionally, single nucleotide polymorphisms in microRNAs (mirSNPs) might be involved in cancer etiology by affecting the related early health damage. To investigate the influence of BTX exposure, mirSNPs, and their interactions on genetic damage, we conducted a cross-sectional study in 1083 Chinese petrochemical workers, quantifying the BTX cumulative exposure levels and multiple genetic damage biomarkers. Additionally, we genotyped multiple common mirSNPs. Benzene and a BTX mixture were positive associated with the olive tail moment (OTM) and tail DNA% (<i>p</i> < 0.05). Higher levels of toluene and xylene enhanced the association of benzene with genetic damage levels. Genotypes and/or mutant allele counts of miR-4482-related rs11191980, miR-4433-related rs136547, miR-27a-related rs2594716, miR-3130-related rs725980, and miR-3928-related rs878718 might significantly influence genetic damage levels. Stronger effect estimates of benzene/BTX exposure were found in carriers of miR-196a-2-related rs11614913 heterozygotes and of wild homozygotes of miR-1269b-related rs12451747, miR-612-related rs12803915, and miR-4804-related rs266437. Our findings provide further support of the involvement of BTX co-exposure, mirSNPs, and their gene–environment interactions in determining the severity of DNA strand break in a complex manner. |
| format | Article |
| id | doaj-art-5cfbe36573804d19a90109c0bcb2c5f8 |
| institution | OA Journals |
| issn | 2305-6304 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj-art-5cfbe36573804d19a90109c0bcb2c5f82025-08-20T02:04:41ZengMDPI AGToxics2305-63042024-11-01121182110.3390/toxics12110821Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical WorkersShuangqi Li0Xiaojing Liao1Rui Ma2Na Deng3Haimei Wu4Zhaorui Zhang5Liping Chen6Qing Wang7Qilong Liao8Qianxi Li9Xinyi Ouyang10Yongmei Xiao11Qifei Deng12Department of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaSchool of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaSchool of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaSchool of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, ChinaSchool of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, ChinaSchool of Public Health, Guangzhou Medical University, Xinzao Road, Panyu District, Guangzhou 511436, ChinaBenzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual and combined effects on genetic damage at low exposure levels are not fully understood. Additionally, single nucleotide polymorphisms in microRNAs (mirSNPs) might be involved in cancer etiology by affecting the related early health damage. To investigate the influence of BTX exposure, mirSNPs, and their interactions on genetic damage, we conducted a cross-sectional study in 1083 Chinese petrochemical workers, quantifying the BTX cumulative exposure levels and multiple genetic damage biomarkers. Additionally, we genotyped multiple common mirSNPs. Benzene and a BTX mixture were positive associated with the olive tail moment (OTM) and tail DNA% (<i>p</i> < 0.05). Higher levels of toluene and xylene enhanced the association of benzene with genetic damage levels. Genotypes and/or mutant allele counts of miR-4482-related rs11191980, miR-4433-related rs136547, miR-27a-related rs2594716, miR-3130-related rs725980, and miR-3928-related rs878718 might significantly influence genetic damage levels. Stronger effect estimates of benzene/BTX exposure were found in carriers of miR-196a-2-related rs11614913 heterozygotes and of wild homozygotes of miR-1269b-related rs12451747, miR-612-related rs12803915, and miR-4804-related rs266437. Our findings provide further support of the involvement of BTX co-exposure, mirSNPs, and their gene–environment interactions in determining the severity of DNA strand break in a complex manner.https://www.mdpi.com/2305-6304/12/11/821BTX co-exposuremicroRNAgenetic polymorphismsgenetic damagegene–environment interactionpetrochemical workers |
| spellingShingle | Shuangqi Li Xiaojing Liao Rui Ma Na Deng Haimei Wu Zhaorui Zhang Liping Chen Qing Wang Qilong Liao Qianxi Li Xinyi Ouyang Yongmei Xiao Qifei Deng Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers Toxics BTX co-exposure microRNA genetic polymorphisms genetic damage gene–environment interaction petrochemical workers |
| title | Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers |
| title_full | Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers |
| title_fullStr | Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers |
| title_full_unstemmed | Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers |
| title_short | Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers |
| title_sort | effects of co exposure to benzene toluene and xylene polymorphisms of microrna genes and their interactions on genetic damage in chinese petrochemical workers |
| topic | BTX co-exposure microRNA genetic polymorphisms genetic damage gene–environment interaction petrochemical workers |
| url | https://www.mdpi.com/2305-6304/12/11/821 |
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