Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility
Aggression constitutes a significant behavioral issue associated with delinquent behavior, commonly observed in youth diagnosed with conduct disorder (CD) and living in correctional facilities. Catechol-o-methyl-transferase <i>(COMT)</i> gene variants modify the environmental sensitivity...
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MDPI AG
2025-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/4/554 |
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| author | Lucija Tudor Josip Podobnik Gordana Nedic Erjavec Matea Nikolac Perkovic Jaanus Harro Margus Kanarik Darko Marcinko Dubravka Svob Strac Melita Cusek Vlatka Kovac Nela Pivac |
| author_facet | Lucija Tudor Josip Podobnik Gordana Nedic Erjavec Matea Nikolac Perkovic Jaanus Harro Margus Kanarik Darko Marcinko Dubravka Svob Strac Melita Cusek Vlatka Kovac Nela Pivac |
| author_sort | Lucija Tudor |
| collection | DOAJ |
| description | Aggression constitutes a significant behavioral issue associated with delinquent behavior, commonly observed in youth diagnosed with conduct disorder (CD) and living in correctional facilities. Catechol-o-methyl-transferase <i>(COMT)</i> gene variants modify the environmental sensitivity associated with the risk of aggression. This study evaluated the association of <i>COMT</i> rs4680 and rs4818 polymorphisms with aggressive behavior in 341 male adolescents living inside and outside a correctional facility, with or without a diagnosis of CD. Aggression was assessed using the Hare Psychopathy Checklist: Youth Version (PCL-YV), Modified Overt Aggression Scale (MOAS) and Swanson, Nolan and Pelham Questionnaire. <i>COMT</i> rs4680 and rs4818 polymorphisms were genotyped using TaqMan SNP Genotyping Assays. A similar prevalence of the <i>COMT</i> genotypes or haplotypes was found between adolescents with or without CD, suicidal behavior, or detention in correctional facility. In youth with CD, the <i>COMT</i> rs4680 A allele was associated with higher MOAS verbal aggression, aggression toward objects, irritability (subjective and open), and PCL-YV interpersonal domain scores compared with carriers of the <i>COMT</i> rs4680 G allele. <i>COMT</i> rs4818 GC carriers with CD had higher scores on the MOAS subjective irritability than GG heterozygotes. These novel findings revealed the association of lower <i>COMT</i> rs4680 and rs4818 activity alleles with aggression in detained male adolescents with CD. |
| format | Article |
| id | doaj-art-5cfae68dfed849c7a2d60ce9f8ddba6a |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-5cfae68dfed849c7a2d60ce9f8ddba6a2025-08-20T03:14:17ZengMDPI AGBiomolecules2218-273X2025-04-0115455410.3390/biom15040554Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional FacilityLucija Tudor0Josip Podobnik1Gordana Nedic Erjavec2Matea Nikolac Perkovic3Jaanus Harro4Margus Kanarik5Darko Marcinko6Dubravka Svob Strac7Melita Cusek8Vlatka Kovac9Nela Pivac10Rudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaDepartment of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, 10000 Zagreb, CroatiaRudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaRudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaNeuropsychopharmacology, Institute of Chemistry, University of Tartu, 50411 Tartu, EstoniaNeuropsychopharmacology, Institute of Chemistry, University of Tartu, 50411 Tartu, EstoniaDepartment of Psychiatry, Clinical Hospital Center Zagreb, 10000 Zagreb, CroatiaRudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaJuvenile Correctional Facility Ivanec, 42240 Ivanec, CroatiaDepartment for Child and Adolescent Psychiatry, Clinical Hospital Center Osijek, 31000 Osijek, CroatiaRudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaAggression constitutes a significant behavioral issue associated with delinquent behavior, commonly observed in youth diagnosed with conduct disorder (CD) and living in correctional facilities. Catechol-o-methyl-transferase <i>(COMT)</i> gene variants modify the environmental sensitivity associated with the risk of aggression. This study evaluated the association of <i>COMT</i> rs4680 and rs4818 polymorphisms with aggressive behavior in 341 male adolescents living inside and outside a correctional facility, with or without a diagnosis of CD. Aggression was assessed using the Hare Psychopathy Checklist: Youth Version (PCL-YV), Modified Overt Aggression Scale (MOAS) and Swanson, Nolan and Pelham Questionnaire. <i>COMT</i> rs4680 and rs4818 polymorphisms were genotyped using TaqMan SNP Genotyping Assays. A similar prevalence of the <i>COMT</i> genotypes or haplotypes was found between adolescents with or without CD, suicidal behavior, or detention in correctional facility. In youth with CD, the <i>COMT</i> rs4680 A allele was associated with higher MOAS verbal aggression, aggression toward objects, irritability (subjective and open), and PCL-YV interpersonal domain scores compared with carriers of the <i>COMT</i> rs4680 G allele. <i>COMT</i> rs4818 GC carriers with CD had higher scores on the MOAS subjective irritability than GG heterozygotes. These novel findings revealed the association of lower <i>COMT</i> rs4680 and rs4818 activity alleles with aggression in detained male adolescents with CD.https://www.mdpi.com/2218-273X/15/4/554aggressionassociationconduct disordercorrectional facility<i>COMT</i> rs4680 and rs4818 polymorphismsgenetic variants |
| spellingShingle | Lucija Tudor Josip Podobnik Gordana Nedic Erjavec Matea Nikolac Perkovic Jaanus Harro Margus Kanarik Darko Marcinko Dubravka Svob Strac Melita Cusek Vlatka Kovac Nela Pivac Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility Biomolecules aggression association conduct disorder correctional facility <i>COMT</i> rs4680 and rs4818 polymorphisms genetic variants |
| title | Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility |
| title_full | Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility |
| title_fullStr | Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility |
| title_full_unstemmed | Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility |
| title_short | Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility |
| title_sort | association of lower comt activity alleles with aggressive traits in male youth with conduct disorder living in a correctional facility |
| topic | aggression association conduct disorder correctional facility <i>COMT</i> rs4680 and rs4818 polymorphisms genetic variants |
| url | https://www.mdpi.com/2218-273X/15/4/554 |
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