GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer’s disease

GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer’s disease

Abstract Background G protein-coupled receptor 43 (GPR43) is a critical signaling molecule involved in maintaining energy balance and immune homeostasis, making it a widely studied drug target. However, its role in Alzheimer’s disease (AD) remains unclear. This study aims to investigate the effects...

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Main Authors: Xiaoqin Wang, Shijing Wu, Zhangjing Deng, Mengyu Yan, Dandan Wang, Maojun Yang, Fuxing Zhong, Jiaqi Song, Lihua Chen, Yingxi Chen, Qi Tian, Weihua Yu, Yang Lü
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Alzheimer’s disease
G protein-coupled receptor 43
Cyclophilin D
Neurons
Synapses
Mitochondria
Online Access:https://doi.org/10.1186/s10020-025-01269-4
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