Shedding light on the cell biology and diverse physiological functions of the migrasome
Abstract The migrasome, an organelle that forms behind migrating cells, is connected to the cell body by a retraction fiber. Once released from the retraction fiber, the migrasome transforms into an extracellular vesicle and plays important roles in cell communication, development, angiogenesis, and...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Cell & Bioscience |
| Online Access: | https://doi.org/10.1186/s13578-025-01417-7 |
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| author | Yuxing Huang Yi Huang Jian Gao |
| author_facet | Yuxing Huang Yi Huang Jian Gao |
| author_sort | Yuxing Huang |
| collection | DOAJ |
| description | Abstract The migrasome, an organelle that forms behind migrating cells, is connected to the cell body by a retraction fiber. Once released from the retraction fiber, the migrasome transforms into an extracellular vesicle and plays important roles in cell communication, development, angiogenesis, and disease. To date, the biogenesis, regulation of formation, cargo transportation, and physiological functions of migrasomes remain largely unknown. In this review, we summarize the current understanding of the mechanisms underlying migrasome formation and regulation, describe the evidence suggesting that migrasomes serve various physiological functions, compare the differences between migrasomes and other extracellular vesicles, emphasize the limitations in studying migrasomes, and discuss the potential of migrasomes in disease diagnosis and treatment. |
| format | Article |
| id | doaj-art-5cf2e74c82374ea3a31e7cf1b65e4324 |
| institution | OA Journals |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-5cf2e74c82374ea3a31e7cf1b65e43242025-08-20T02:03:34ZengBMCCell & Bioscience2045-37012025-05-0115111010.1186/s13578-025-01417-7Shedding light on the cell biology and diverse physiological functions of the migrasomeYuxing Huang0Yi Huang1Jian Gao2Department of Obstetrics and Gynecology, Peking University First hospitalDepartment of Respiratory Medicine, Nankang Hospital of Traditional Chinese MedicineDepartment of Thoracic Surgery, Peking University People’s HospitalAbstract The migrasome, an organelle that forms behind migrating cells, is connected to the cell body by a retraction fiber. Once released from the retraction fiber, the migrasome transforms into an extracellular vesicle and plays important roles in cell communication, development, angiogenesis, and disease. To date, the biogenesis, regulation of formation, cargo transportation, and physiological functions of migrasomes remain largely unknown. In this review, we summarize the current understanding of the mechanisms underlying migrasome formation and regulation, describe the evidence suggesting that migrasomes serve various physiological functions, compare the differences between migrasomes and other extracellular vesicles, emphasize the limitations in studying migrasomes, and discuss the potential of migrasomes in disease diagnosis and treatment.https://doi.org/10.1186/s13578-025-01417-7 |
| spellingShingle | Yuxing Huang Yi Huang Jian Gao Shedding light on the cell biology and diverse physiological functions of the migrasome Cell & Bioscience |
| title | Shedding light on the cell biology and diverse physiological functions of the migrasome |
| title_full | Shedding light on the cell biology and diverse physiological functions of the migrasome |
| title_fullStr | Shedding light on the cell biology and diverse physiological functions of the migrasome |
| title_full_unstemmed | Shedding light on the cell biology and diverse physiological functions of the migrasome |
| title_short | Shedding light on the cell biology and diverse physiological functions of the migrasome |
| title_sort | shedding light on the cell biology and diverse physiological functions of the migrasome |
| url | https://doi.org/10.1186/s13578-025-01417-7 |
| work_keys_str_mv | AT yuxinghuang sheddinglightonthecellbiologyanddiversephysiologicalfunctionsofthemigrasome AT yihuang sheddinglightonthecellbiologyanddiversephysiologicalfunctionsofthemigrasome AT jiangao sheddinglightonthecellbiologyanddiversephysiologicalfunctionsofthemigrasome |