Applications, Limitations, and Considerations of Clinical Trials in a Dish
Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/11/1096 |
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| author | Amatullah Mir Angie Zhu Rico Lau Nicolás Barr Zyva Sheikh Diana Acuna Anuhya Dayal Narutoshi Hibino |
| author_facet | Amatullah Mir Angie Zhu Rico Lau Nicolás Barr Zyva Sheikh Diana Acuna Anuhya Dayal Narutoshi Hibino |
| author_sort | Amatullah Mir |
| collection | DOAJ |
| description | Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies. Furthermore, this review dissects the advantages and disadvantages of CTiDs, as well as their regulatory considerations. Lastly, we evaluate the challenges that CTiDs pose and the role of CTiDs in future experimentation. |
| format | Article |
| id | doaj-art-5cf0b90a8b844bc1ba7ce048b45a2f35 |
| institution | OA Journals |
| issn | 2306-5354 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-5cf0b90a8b844bc1ba7ce048b45a2f352025-08-20T02:28:01ZengMDPI AGBioengineering2306-53542024-10-011111109610.3390/bioengineering11111096Applications, Limitations, and Considerations of Clinical Trials in a DishAmatullah Mir0Angie Zhu1Rico Lau2Nicolás Barr3Zyva Sheikh4Diana Acuna5Anuhya Dayal6Narutoshi Hibino7Section of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USASection of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USASection of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USASection of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USASection of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USASection of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USASection of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USASection of Cardiac Surgery, Department of Surgery, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USARecent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies. Furthermore, this review dissects the advantages and disadvantages of CTiDs, as well as their regulatory considerations. Lastly, we evaluate the challenges that CTiDs pose and the role of CTiDs in future experimentation.https://www.mdpi.com/2306-5354/11/11/1096iPSCsorgan-on-a-chipclinical trials in dishbioprintingtissue engineeringvasculature |
| spellingShingle | Amatullah Mir Angie Zhu Rico Lau Nicolás Barr Zyva Sheikh Diana Acuna Anuhya Dayal Narutoshi Hibino Applications, Limitations, and Considerations of Clinical Trials in a Dish Bioengineering iPSCs organ-on-a-chip clinical trials in dish bioprinting tissue engineering vasculature |
| title | Applications, Limitations, and Considerations of Clinical Trials in a Dish |
| title_full | Applications, Limitations, and Considerations of Clinical Trials in a Dish |
| title_fullStr | Applications, Limitations, and Considerations of Clinical Trials in a Dish |
| title_full_unstemmed | Applications, Limitations, and Considerations of Clinical Trials in a Dish |
| title_short | Applications, Limitations, and Considerations of Clinical Trials in a Dish |
| title_sort | applications limitations and considerations of clinical trials in a dish |
| topic | iPSCs organ-on-a-chip clinical trials in dish bioprinting tissue engineering vasculature |
| url | https://www.mdpi.com/2306-5354/11/11/1096 |
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