Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis
Abstract Environmental ‘light’ has a vital role in regulating plant growth and development. Transcriptomic profiling has been widely used to examine how light regulates mRNA levels on a genome‐wide scale, but the global role of translational regulation in the response to light is unknown. Through a...
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| Format: | Article |
| Language: | English |
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Springer Nature
2012-01-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2011.97 |
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| author | Ming‐Jung Liu Szu‐Hsien Wu Ho‐Ming Chen Shu‐Hsing Wu |
| author_facet | Ming‐Jung Liu Szu‐Hsien Wu Ho‐Ming Chen Shu‐Hsing Wu |
| author_sort | Ming‐Jung Liu |
| collection | DOAJ |
| description | Abstract Environmental ‘light’ has a vital role in regulating plant growth and development. Transcriptomic profiling has been widely used to examine how light regulates mRNA levels on a genome‐wide scale, but the global role of translational regulation in the response to light is unknown. Through a transcriptomic comparison of steady‐state and polysome‐bound mRNAs, we reveal a clear impact of translational control on thousands of genes, in addition to transcriptomic changes, during photomorphogenesis. Genes encoding ribosomal protein are preferentially regulated at the translational level, which possibly contributes to the enhanced translation efficiency. We also reveal that mRNAs regulated at the translational level share characteristics of longer half‐lives and shorter cDNA length, and that transcripts with a cis‐element, TAGGGTTT, in their 5′ untranslated region have higher translatability. We report a previously neglected aspect of gene expression regulation during Arabidopsis photomorphogenesis. The identities and molecular signatures associated with mRNAs regulated at the translational level also offer new directions for mechanistic studies of light‐triggered translational enhancement in Arabidopsis. |
| format | Article |
| id | doaj-art-5ceea74a796b4a79a829bbd4aef9a9d3 |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-5ceea74a796b4a79a829bbd4aef9a9d32025-08-20T04:02:44ZengSpringer NatureMolecular Systems Biology1744-42922012-01-018111410.1038/msb.2011.97Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesisMing‐Jung Liu0Szu‐Hsien Wu1Ho‐Ming Chen2Shu‐Hsing Wu3Institute of Plant and Microbial Biology, Academia SinicaInstitute of Plant and Microbial Biology, Academia SinicaInstitute of Plant and Microbial Biology, Academia SinicaInstitute of Plant and Microbial Biology, Academia SinicaAbstract Environmental ‘light’ has a vital role in regulating plant growth and development. Transcriptomic profiling has been widely used to examine how light regulates mRNA levels on a genome‐wide scale, but the global role of translational regulation in the response to light is unknown. Through a transcriptomic comparison of steady‐state and polysome‐bound mRNAs, we reveal a clear impact of translational control on thousands of genes, in addition to transcriptomic changes, during photomorphogenesis. Genes encoding ribosomal protein are preferentially regulated at the translational level, which possibly contributes to the enhanced translation efficiency. We also reveal that mRNAs regulated at the translational level share characteristics of longer half‐lives and shorter cDNA length, and that transcripts with a cis‐element, TAGGGTTT, in their 5′ untranslated region have higher translatability. We report a previously neglected aspect of gene expression regulation during Arabidopsis photomorphogenesis. The identities and molecular signatures associated with mRNAs regulated at the translational level also offer new directions for mechanistic studies of light‐triggered translational enhancement in Arabidopsis.https://doi.org/10.1038/msb.2011.97photomorphogenesispolysometranslation |
| spellingShingle | Ming‐Jung Liu Szu‐Hsien Wu Ho‐Ming Chen Shu‐Hsing Wu Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis Molecular Systems Biology photomorphogenesis polysome translation |
| title | Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis |
| title_full | Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis |
| title_fullStr | Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis |
| title_full_unstemmed | Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis |
| title_short | Widespread translational control contributes to the regulation of Arabidopsis photomorphogenesis |
| title_sort | widespread translational control contributes to the regulation of arabidopsis photomorphogenesis |
| topic | photomorphogenesis polysome translation |
| url | https://doi.org/10.1038/msb.2011.97 |
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